Li Haicheng, Zhang Changxing, Feng Xue
AML, Department of Engineering Mechanics, Tsinghua University, Beijing, 100084, China.
Center for Flexible Electronics Technology, Tsinghua University, Beijing, 100084, China.
Biomed Opt Express. 2019 Jan 24;10(2):868-878. doi: 10.1364/BOE.10.000868. eCollection 2019 Feb 1.
Measurement techniques based on optics, with the characteristics of noninvasive or non-destructive detection and high accuracy, offer excellent properties for application in various scenarios. Skin-like optical devices capable of deforming with human skin play major roles in future biomedical applications such as clinical diagnostics or biological healthcare. Unlike traditional rigid devices, the skin-like optical device is conformal to the skin because of the flexibility and stretchability. However, the detected signals based on light intensity are very sensitive to the light path. As a result, the accuracy and efficiency of the skin-like device will be influenced owing to deformation. In this work, for optimizing the design of the skin-like optical device, we use the Monte Carlo method to investigate the light distribution after scattered and absorbed by a human tissue. Different parameters of light source and blood vessels are used to simulate the device and human tissue deformation respectively. The characteristics of the exited light are then summarized and analyzed to study the influence of the deformation. The simulation shows that the deformation of the device and human tissue will produce non-linear effects on the characteristics of the exited lights. Finally, we design and fabricate a skin-like device using the simulation results and use it to monitor photoplethysmogram signals. This work will aid in the design of skin-like optical devices in the future.
基于光学的测量技术具有非侵入性或非破坏性检测以及高精度的特点，在各种场景中具有出色的应用性能。能够随人体皮肤变形的类皮肤光学器件在未来生物医学应用中发挥着重要作用，如临床诊断或生物医疗保健。与传统的刚性器件不同，类皮肤光学器件由于具有柔韧性和可拉伸性，能够与皮肤贴合。然而，基于光强的检测信号对光路非常敏感。因此，类皮肤器件的精度和效率会因变形而受到影响。在这项工作中，为了优化类皮肤光学器件的设计，我们使用蒙特卡罗方法来研究光在人体组织中散射和吸收后的光分布。分别使用不同的光源参数和血管参数来模拟器件和人体组织的变形。然后总结并分析出射光的特性，以研究变形的影响。模拟结果表明，器件和人体组织的变形会对出射光的特性产生非线性影响。最后，我们根据模拟结果设计并制作了一个类皮肤器件，并使用它来监测光电容积脉搏波信号。这项工作将有助于未来类皮肤光学器件的设计。
