AML, Department of Engineering Mechanics, Tsinghua University, Beijing 100084, China.
Center for Flexible Electronics Technology, Tsinghua University, Beijing 100084, China.
Sci Adv. 2017 Dec 20;3(12):e1701629. doi: 10.1126/sciadv.1701629. eCollection 2017 Dec.
Currently, noninvasive glucose monitoring is not widely appreciated because of its uncertain measurement accuracy, weak blood glucose correlation, and inability to detect hyperglycemia/hypoglycemia during sleep. We present a strategy to design and fabricate a skin-like biosensor system for noninvasive, in situ, and highly accurate intravascular blood glucose monitoring. The system integrates an ultrathin skin-like biosensor with paper battery-powered electrochemical twin channels (ETCs). The designed subcutaneous ETCs drive intravascular blood glucose out of the vessel and transport it to the skin surface. The ultrathin (~3 μm) nanostructured biosensor, with high sensitivity (130.4 μA/mM), fully absorbs and measures the glucose, owing to its extreme conformability. We conducted in vivo human clinical trials. The noninvasive measurement results for intravascular blood glucose showed a high correlation (>0.9) with clinically measured blood glucose levels. The system opens up new prospects for clinical-grade noninvasive continuous glucose monitoring.
目前，由于无创血糖监测的测量精度不确定、与血糖的相关性弱，以及无法检测睡眠期间的高血糖/低血糖，因此并未得到广泛认可。我们提出了一种设计和制造用于无创、原位和高精度血管内血糖监测的仿生皮肤传感器系统的策略。该系统将超薄仿生皮肤传感器与纸电池供电的电化学双通道（ETC）集成在一起。设计的皮下 ETC 将血管内的血糖驱出血管并将其输送到皮肤表面。超薄（~3 μm）纳米结构的生物传感器具有极高的灵敏度（130.4 μA/mM），由于其极好的顺应性，可完全吸收和测量葡萄糖。我们进行了人体临床试验。血管内血糖的无创测量结果与临床测量的血糖水平具有高度相关性（>0.9）。该系统为临床级别的无创连续血糖监测开辟了新的前景。
