Digestive Health Institute, Children's Hospital Colorado and University of Colorado School of Medicine.
Department of Psychiatry, University of Colorado School of Medicine.
J Pediatr Gastroenterol Nutr. 2019 Mar;68(3):348-352. doi: 10.1097/MPG.0000000000002189.
The aim of the study was to describe use of oral or sublingual cannabis oil (CO) by adolescent and young adult patients with inflammatory bowel disease (IBD).
A descriptive study of IBD patients 13 to 23 years of age seen between January 2015 through December 2017 at Children's Hospital Colorado. Information obtained included chart abstraction, electronic and interview self-report, and serum cannabinoid levels. We compared CO users and cannabis non-users for clinical characteristics and perceptions of risk. Users of CO provided information on routes, patterns, motivations, and perceived benefits and problems with use.
The 15 users and 67 non-users were similar for clinical characteristics and pain and appetite scores. 9 of 15 (60%) CO users had used in the past 30 days, an average of 22 ± 9 times; and 4 used daily. A variety of strengths and CBD:THC ratios were reported. Most common perceived effect of use was on sleep quality, nausea, and increase in appetite. Of the 15 users, 6 used only CO and no additional forms of cannabis. Of these 6 CO only users, 5 reported a medical reason for use, most commonly to relieve pain.
Adolescent and young adults with IBD used oral CO and many used other cannabis products as well. Users perceived some medical benefit. Care teams should strive for open communication about use until further information on safety and efficacy becomes available.
本研究旨在描述青少年和年轻成年炎症性肠病（IBD）患者口服或舌下使用大麻油（CO）的情况。
这是一项描述性研究，纳入了 2015 年 1 月至 2017 年 12 月在科罗拉多儿童医院就诊的 13 至 23 岁的 IBD 患者。收集的信息包括图表摘录、电子和访谈自我报告以及血清大麻素水平。我们比较了 CO 使用者和非使用者的临床特征以及对风险的认知。CO 使用者提供了关于途径、模式、动机以及使用的好处和问题的信息。
15 名 CO 使用者和 67 名非使用者在临床特征和疼痛、食欲评分方面相似。15 名 CO 使用者中有 9 名（60%）在过去 30 天内使用过，平均使用 22±9 次；4 名患者每天使用。报告了各种 CO 的强度和 CBD：THC 比例。最常见的使用效果是改善睡眠质量、缓解恶心和增加食欲。在 15 名使用者中，有 6 名仅使用 CO，未使用其他形式的大麻。这 6 名仅使用 CO 的患者中，有 5 名报告使用 CO 是出于医疗原因，最常见的是缓解疼痛。
IBD 的青少年和年轻成年人使用口服 CO，许多人也使用其他大麻制品。使用者认为有一定的医疗益处。在获得关于安全性和疗效的进一步信息之前，医疗团队应努力就使用情况进行开放沟通。
