Division of Diabetes, Endocrinology and Metabolism, Faculty of Medicine, Imperial College, London, UK.
Diabet Med. 2020 Apr;37(4):532-544. doi: 10.1111/dme.13942. Epub 2019 Mar 13.
Real-time continuous glucose monitors using subcutaneous needle-type sensors continue to develop. The limitations of currently available systems, however, include time lag behind changes in blood glucose, the invasive nature of such systems, and in some cases, their accuracy. Non-invasive techniques have been developed, but, to date, no commercial device has been successful. A key research priority for people with Type 1 diabetes identified by the James Lind Alliance was to identify ways of monitoring blood glucose constantly and accurately using a discrete device, invasive or non-invasive. Integration of such a sensor is important in the development of a closed-loop system and the technology must be rapid, selective and acceptable for continuous use by individuals. The present review provides an update on existing continuous glucose-sensing technologies, and an overview of emergent techniques, including their accuracy and limitations.
使用皮下针型传感器的实时连续血糖监测仪不断发展。然而，现有系统的局限性包括与血糖变化之间的时间滞后、此类系统的侵入性，以及在某些情况下其准确性。已经开发出非侵入性技术，但迄今为止，没有一种商业设备获得成功。詹姆斯林德联盟确定的 1 型糖尿病患者的一个关键研究重点是确定如何使用离散设备以无创或有创的方式持续且准确地监测血糖。此类传感器的集成对于闭环系统的发展很重要，该技术必须快速、具有选择性，并能被个人持续使用。本综述提供了对现有连续血糖传感技术的最新更新，并概述了新兴技术，包括它们的准确性和局限性。
