中国儿童中釉基质蛋白（ENAM）、成纤维细胞生长因子诱导转录因子1（TUFT1）、基质金属蛋白酶13（MMP13）、白细胞介素1β（IL1B）、白细胞介素10（IL10）和白细胞介素1受体拮抗剂（IL1RN）基因多态性与龋齿易感性的关联
Association of ENAM, TUFT1, MMP13, IL1B, IL10 and IL1RN gene polymorphism and dental caries susceptibility in Chinese children.
作者信息
Hu Xiao-Pan, Song Tian-Zhu, Zhu Yan-Yan, Wu Ling-Li, Zhang Xuan, Zhou Jian-Ye, Li Zhi-Qiang
机构信息
1 School of Stomatology, Northwest Minzu University, Lanzhou, Gansu Province, China.
2 Key Laboratory of Oral Diseases of Gansu Province, Lanzhou, Gansu Province, China.
出版信息
J Int Med Res. 2019 Apr;47(4):1696-1704. doi: 10.1177/0300060519828450. Epub 2019 Feb 25.
OBJECTIVE
To investigate the association between single nucleotide polymorphisms (SNPs) in six candidate genes (enamelin [ ENAM]; tuftelin 1 [ TUFT1]; matrix metallopeptidase 13 [ MMP13]; interleukin 1 beta [ IL1B]; interleukin 10 [ IL10]; interleukin 1 receptor antagonist [ IL1RN]) and dental caries in children from northwest China.
METHODS
This case-control study enrolled children (12-15 years) who underwent routine dental examinations. The children were divided into two groups based on the presence of dental caries. A saliva sample was collected and seven SNPs (rs3806804A/G in ENAM, rs3811411T/G in TUFT1, rs2252070A/G and rs597315A/T in MMP13, rs1143627C/T in IL1B, rs1800872A/C in IL10 and rs956730G/A in IL1RN) were genotyped.
RESULTS
A total of 357 children were enrolled in the study: 161 with dental caries and 196 without dental caries. No significant difference was found in the alleles and genotypes of five genes ( ENAM, TUFT1, MMP13, IL10 and IL1RN) between those with and without dental caries. A significant relationship was found between the IL1B rs1143627C/T polymorphism and dental caries susceptibility with those carrying the rs1143627CT genotype having a lower risk of dental caries compared with those carrying the CC genotype (odds ratio 0.557; 95% confidence interval 0.326, 0.952).
CONCLUSION
The IL1B rs1143627C/T polymorphism may be associated with dental caries susceptibility in children from northwest China.
目的
研究六个候选基因（釉蛋白[ENAM]；牙丛蛋白1[TUFT1]；基质金属蛋白酶13[MMP13]；白细胞介素1β[IL1B]；白细胞介素10[IL10]；白细胞介素1受体拮抗剂[IL1RN]）中的单核苷酸多态性（SNP）与中国西北地区儿童龋齿之间的关联。
方法
本病例对照研究纳入了接受常规牙科检查的儿童（12 - 15岁）。根据是否患有龋齿将儿童分为两组。收集唾液样本，并对七个SNP（ENAM中的rs3806804A/G、TUFT1中的rs3811411T/G、MMP13中的rs2252070A/G和rs597315A/T、IL1B中的rs1143627C/T、IL10中的rs1800872A/C以及IL1RN中的rs956730G/A）进行基因分型。
结果
共有357名儿童参与本研究：161名患有龋齿，196名未患龋齿。在患龋齿和未患龋齿的儿童之间，五个基因（ENAM、TUFT1、MMP13、IL10和IL1RN）的等位基因和基因型未发现显著差异。发现IL1B rs1143627C/T多态性与龋齿易感性之间存在显著关系，与携带CC基因型的儿童相比，携带rs1143627CT基因型的儿童患龋齿风险较低（优势比0.557；95%置信区间0.326，0.952）。
结论
IL1B rs1143627C/T多态性可能与中国西北地区儿童的龋齿易感性有关。
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