Department of Endodontics, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, 6713954658, Iran.
Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah, 6715847141, Iran.
BMC Oral Health. 2020 May 6;20(1):132. doi: 10.1186/s12903-020-01121-7.
This meta-analysis evaluated the association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility.
We searched the Scopus, PubMed/Medline, Web of Science, and Cochrane Library databases to retrieve articles published by October 2019. Review Manager 5.3 software was used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs). The results of publication bias tests were retrieved by Comprehensive Meta-Analysis 2.0 software.
A total of 150 relevant records were identified; out of which, 16 were entered into the analysis (4 studies assessed LTF, 11 ENAM, and 11 AMELX polymorphisms). Of all polymorphisms, there was a significant association only between ENAM rs3796704 polymorphism and dental caries susceptibility. Both ENAM rs3796704 and AMELX rs17878486 polymorphisms had a significant association with dental caries risk in the Caucasian ethnicity and the studies including caries-free control group.
The results of this meta-analysis showed that the G allele and the GG genotype of ENAM rs3796704 were associated with an increased risk of caries in the case group compared with the control group. But there was no association between LTF rs1126478, ENAM (rs1264848 and rs3796703), and AMELX (rs946252, rs17878486, and rs2106416) polymorphisms and dental caries susceptibility.
本荟萃分析评估了 LTF、ENAM 和 AMELX 多态性与龋齿易感性的关联。
我们检索了 Scopus、PubMed/Medline、Web of Science 和 Cochrane Library 数据库，以检索截至 2019 年 10 月发表的文章。使用 Review Manager 5.3 软件估计优势比（OR）和 95%置信区间（CI）。综合荟萃分析 2.0 软件用于检索发表偏倚测试的结果。
共确定了 150 条相关记录，其中 16 条进入分析（4 项研究评估了 LTF、11 项 ENAM 和 11 项 AMELX 多态性）。在所有多态性中，仅 ENAM rs3796704 多态性与龋齿易感性显著相关。ENAM rs3796704 和 AMELX rs17878486 多态性在白种人种族和包括无龋对照组的研究中与龋齿风险显著相关。
这项荟萃分析的结果表明，与对照组相比，ENAM rs3796704 的 G 等位基因和 GG 基因型与病例组的龋齿风险增加相关。但是，LTF rs1126478、ENAM（rs1264848 和 rs3796703）和 AMELX（rs946252、rs17878486 和 rs2106416）多态性与龋齿易感性之间没有关联。
