中国儿童维生素D受体基因多态性与乳牙龋齿的关系。
The relationship between vitamin D receptor gene polymorphism and deciduous tooth decay in Chinese children.
作者信息
Kong Yuan-Yuan, Zheng Jian-Mao, Zhang Wen-Juan, Jiang Qian-Zhou, Yang Xue-Chao, Yu Miao, Zeng Su-Juan
机构信息
Key Laboratory of Oral Medicine, Guangzhou Institute of Oral Disease, Stomatology Hospital of Guangzhou Medical University, 39# Huangsha Road, Guangzhou, 510140, China.
Department of Endodontics, Stomatology Hospital of Guangzhou Medical University, Guangzhou, 510140, China.
出版信息
BMC Oral Health. 2017 Jul 11;17(1):111. doi: 10.1186/s12903-017-0398-x.
BACKGROUND
In the present study, we explored the link between vitamin D receptor (VDR) BsmI, TaqI, ApaI and FokI gene polymorphisms with deciduous tooth decay in Chinese children.
METHODS
Our study included 380 Chinese children aged 4-7 years, whose DNA sample was collected from the buccal mucosa. VDR gene polymorphisms was determined by PCR-RFLP.
RESULTS
The adjusted logistic regression analysis demonstrated that BsmI containing the Bb genotype was linked with the increased risk of deciduous tooth decay (OR = 1.856, 95% CI = [1.184, 2.908], p = 0.007). However, VDR polymorphisms ApaI, TaqI and FokI were not associated with deciduous tooth decay (ApaI: OR = 0.839, 95% CI = [0.614, 1.145], p = 0.268; TaqI: OR = 1.150, 95% CI = [0.495, 2.672], p = 0.744; FokI: OR = 0.856, 95% CI = [0.616, 1.191], p = 0.356).
CONCLUSIONS
Our results showed that VDR BsmI polymorphism was associated with the risk of deciduous tooth decay in Chinese children aged 4-7 years. However, the specific mechanism remains to further verify through experiment.
背景
在本研究中，我们探究了维生素D受体（VDR）的BsmI、TaqI、ApaI和FokI基因多态性与中国儿童乳牙龋齿之间的联系。
方法
我们的研究纳入了380名4至7岁的中国儿童，从其颊黏膜采集DNA样本。通过聚合酶链反应-限制性片段长度多态性分析（PCR-RFLP）确定VDR基因多态性。
结果
校正后的逻辑回归分析表明，携带Bb基因型的BsmI与乳牙龋齿风险增加有关（比值比[OR]=1.856，95%置信区间[CI]=[1.184, 2.908]，p=0.007）。然而，VDR基因多态性ApaI、TaqI和FokI与乳牙龋齿无关（ApaI：OR=0.839，95%CI=[0.614, 1.145]，p=0.268；TaqI：OR=1.150，95%CI=[0.495, 2.672]，p=0.744；FokI：OR=0.856，95%CI=[0.616, 1.191]，p=0.356）。
结论
我们的结果表明，VDR的BsmI多态性与4至7岁中国儿童乳牙龋齿风险有关。然而，具体机制仍有待通过实验进一步验证。
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