Ehime University School of Medicine, Toon, Japan.
Laboratory of Community Health and Nutrition, Special Course of Food and Health Science, Department of Bioscience, Graduate School of Agriculture, Ehime University, 3-5-7 Tarumi, Matsuyama, Ehime, 790-8566, Japan.
Sleep Breath. 2019 Dec;23(4):1027-1031. doi: 10.1007/s11325-019-01815-5. Epub 2019 Feb 26.
Coffee is a major caffeine-containing food source that can be used for treatment of apnea in prematurity. However, few studies have examined the association between coffee consumption and sleep-disordered breathing (SDB). We investigated whether coffee consumption is associated with the oxygen desaturation index (ODI) as a marker of SDB among middle-aged Japanese male workers.
The subjects were 1126 male local government workers aged 22-59 who participated in SDB screening in 2011-2012. Daily coffee consumption was assessed by a self-administered questionnaire. We measured 3% oxygen desaturation (3%ODI) during a night's sleep using a pulse oximeter. A general linear model was used to calculate the multivariate-adjusted means of 3%ODI per quartile of coffee consumption. We further analyzed the data after stratifying by overweight and current smoking status.
A inverse association between coffee consumption and 3%ODI was found. The multivariate-adjusted mean of 3%ODI for the lowest and highest coffee consumption groups were 11.9 times/h and 10.6 times/h (p for trend = 0.06), respectively; 14.6 and 11.5 times/h (p for trend = 0.01) in overweight participants; and 12.7 and 11.0 times/h (p for trend = 0.06) in non-smokers. No associations were found in non-overweight and smoking workers.
Our results suggest that higher coffee consumption was associated with lower 3% ODI as a marker of SDB in overweight and non-smoking workers.
咖啡是一种主要的含咖啡因食物来源，可用于治疗早产儿的呼吸暂停。然而，很少有研究探讨咖啡摄入与睡眠呼吸障碍（SDB）之间的关系。我们调查了在中年日本男性工人中，咖啡摄入是否与作为 SDB 标志物的氧减饱和指数（ODI）相关。
研究对象为 2011-2012 年参加睡眠呼吸暂停筛查的 1126 名年龄在 22-59 岁的当地政府男性工作人员。通过自我管理问卷评估每日咖啡摄入量。我们使用脉搏血氧仪测量夜间 3%的氧减饱和（3%ODI）。使用一般线性模型计算咖啡摄入量每四分位数的 3%ODI 的多变量调整均值。我们还按超重和当前吸烟状况进行分层后分析数据。
咖啡摄入与 3%ODI 呈负相关。最低和最高咖啡摄入量组的 3%ODI 的多变量调整均值分别为 11.9 次/小时和 10.6 次/小时（趋势检验 p = 0.06）；在超重参与者中，分别为 14.6 次/小时和 11.5 次/小时（趋势检验 p = 0.01）；在不吸烟者中，分别为 12.7 次/小时和 11.0 次/小时（趋势检验 p = 0.06）。在非超重和吸烟者中未发现相关性。
我们的结果表明，在超重和不吸烟者中，较高的咖啡摄入量与较低的 3%ODI 作为 SDB 的标志物相关。
