Rogers Amy E, Lu Xiaoyan, Killerby Marie, Campbell Elizabeth, Gallus Linda, Kamau Edwin, Froh Irma B, Nowak Gosia, Erdman Dean D, Sakthivel Senthilkumar K, Gerber Susan I, Schneider Eileen, Watson John T, Johnson Lucas A
MSMR. 2019 Feb;26(2):21-27.
Human adenoviruses (HAdVs) are known to cause respiratory illness outbreaks at basic military training (BMT) sites. HAdV type-4 and -7 vaccines are routinely administered at enlisted BMT sites, but not at military academies. During August-September 2016, U.S. Naval Academy clinical staff noted an increase in students presenting with acute respiratory illness (ARI). An investigation was conducted to determine the extent and cause of the outbreak. During 22 August-11 September 2016, 652 clinic visits for ARI were identified using electronic health records. HAdV-4 was confirmed by realtime polymerase chain reaction assay in 18 out of 33 patient specimens collected and 1 additional HAdV case was detected from hospital records. Two HAdV-4 positive patients were treated for pneumonia including 1 hospitalized patient. Molecular analysis of 4 HAdV-4 isolates identified genome type 4a1, which is considered vaccine-preventable. Understanding the impact of HAdV in congregate settings other than enlisted BMT sites is necessary to inform discussions regarding future HAdV vaccine strategy.
已知人类腺病毒（HAdVs）会在基础军事训练（BMT）场所引发呼吸道疾病暴发。4型和7型HAdV疫苗通常在入伍新兵的BMT场所接种，但军事院校不接种。2016年8月至9月期间，美国海军学院临床工作人员注意到出现急性呼吸道疾病（ARI）的学生人数增加。开展了一项调查以确定此次暴发的范围和原因。在2016年8月22日至9月11日期间，利用电子健康记录确定了652例ARI门诊病例。在采集的33份患者标本中，有18份经实时聚合酶链反应检测确诊为4型HAdV，另外从医院记录中又检测出1例HAdV病例。两名4型HAdV阳性患者因肺炎接受治疗，其中1例住院。对4株4型HAdV分离株的分子分析确定为4a1基因组类型，这被认为是可通过疫苗预防的。了解HAdV在入伍新兵BMT场所以外的集体环境中的影响，对于为未来HAdV疫苗策略的讨论提供信息很有必要。
