半乳糖凝集素-3 与血液透析患者的动脉僵硬有关。
Galectin-3 is associated with arterial stiffness among hemodialysis patients.
机构信息
Division of Nephrology, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200011, PR China.
Department of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, PR China.
出版信息
Biomark Med. 2019 Apr;13(6):437-443. doi: 10.2217/bmm-2018-0488. Epub 2019 Feb 27.
To evaluate the association between galectin-3 and arterial stiffness among hemodialysis patients. We enrolled 311 patients (median age: 61 years) with a median hemodialysis time of 90 months and a mean galectin-3 concentration of 29.78 ng/ml. Ninety-six (30.7%) had arterial stiffness diagnosed by the pulse-wave velocity over 10 m/s. Galectin-3 was significantly associated with dialysis vintage, calcium, phosphorus and low-density lipoprotein. After adjustment for multiple cardiovascular risk factors, galectin-3 was independently associated with the pulse-wave velocity (partial = 0.130; p = 0.035). This effect was still significant after additional adjustment for mean arterial pressure and single-pool Kt/V (partial = 0.139; p = 0.014). Galectin-3 is independently associated with arterial stiffness among hemodialysis patients.
评估半乳糖凝集素-3 与血液透析患者动脉僵硬之间的关系。我们纳入了 311 名患者（中位年龄：61 岁），中位血液透析时间为 90 个月，半乳糖凝集素-3 浓度的平均值为 29.78ng/ml。96 名患者（30.7%）的脉搏波速度超过 10m/s，被诊断为动脉僵硬。半乳糖凝集素-3 与透析时间、钙、磷和低密度脂蛋白显著相关。调整多个心血管危险因素后，半乳糖凝集素-3 与脉搏波速度独立相关（偏相关系数 0.130；p=0.035）。在进一步调整平均动脉压和单池 Kt/V 后，这种相关性仍然显著（偏相关系数 0.139；p=0.014）。半乳糖凝集素-3 与血液透析患者的动脉僵硬独立相关。
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