Vernet O, Christin L, Schutz Y, Danforth E, Jequier E
Am J Physiol. 1986 Jan;250(1 Pt 1):E47-54. doi: 10.1152/ajpendo.1986.250.1.E47.
Continuous respiratory exchange measurements were performed on 10 healthy young women for 1 h before, 3 h during, and 3 h after either parenteral (iv) or intragastric (ig) administration of a nutrient mixture (52% glucose, 18% amino acid, and 30% lipid energy) infused at twice the postabsorptive resting energy expenditure (REE). REE rose from 0.98 +/- 0.02 (iv) and 0.99 +/- 0.02 kcal/min (ig) postabsorptively to 1.13 +/- 0.03 (iv) and 1.13 +/- 0.02 kcal/min (ig), resulting in nutrient-induced thermogenesis of 10 +/- 0.6 and 9.3 +/- 0.9%, respectively, when related to the metabolizable energy. The respiratory quotient rose from preinfusion values of 0.81 +/- 0.02 (iv) and 0.80 +/- 0.01 (ig) to 0.86 +/- 0.01 (iv) and 0.85 +/- 0.01 (ig). After nutrient administration the respiratory quotient fell significantly to below the preinfusion values. Plasma glucose and insulin concentrations rose during nutrient administration but were higher during the intravenous route. It is concluded that, although the response time to intragastric administration was delayed, the thermic effects and overall substrate oxidations were comparable during intravenous or intragastric administration, albeit, at lower plasma glucose and insulin concentrations via the intragastric route.
对10名健康年轻女性进行了连续呼吸交换测量，在经胃肠外（静脉注射）或胃内（灌胃）给予营养混合物（52%葡萄糖、18%氨基酸和30%脂质能量）之前1小时、给药期间3小时以及给药后3小时进行测量，该营养混合物的输注速度为吸收后静息能量消耗（REE）的两倍。吸收后REE从静脉注射时的0.98±0.02和灌胃时的0.99±0.02千卡/分钟分别升至1.13±0.03（静脉注射）和1.13±0.02千卡/分钟（灌胃），与可代谢能量相关时，营养诱导的产热分别为10±0.6%和9.3±0.9%。呼吸商从输注前静脉注射时的0.81±0.02和灌胃时的0.80±0.01升至静脉注射时的0.86±0.01和灌胃时的0.85±0.01。给予营养物质后，呼吸商显著下降至低于输注前的值。营养物质给药期间血浆葡萄糖和胰岛素浓度升高，但静脉途径时更高。结论是，尽管胃内给药的反应时间延迟，但静脉注射或胃内给药期间的热效应和总体底物氧化是可比的，尽管通过胃内途径血浆葡萄糖和胰岛素浓度较低。
