低强度聚焦超声治疗脑部疾病：安全性和可行性。
Low-intensity focused ultrasound for the treatment of brain diseases: safety and feasibility.
机构信息
Endovascular Neurosurgery, Università di Catania, Catania, Italy.
Neurosurgery Department, Università di Catania, Catania, Italy.
出版信息
Theranostics. 2019 Jan 1;9(2):537-539. doi: 10.7150/thno.31765. eCollection 2019.
Abstract
The use of focused ultrasound (FUS) as a tool for blood-brain barrier (BBB) permeabilization is opening new ways for the treatment of several pathologies, in particular brain tumors and neurodegenerative diseases. However, even if there are promising results in these fields, the efficacy and safety of this technique is unknown in long-term follow-up. The study of Blackmore et al. [Theranostics 2018; 8(22):6233-6247. doi:10.7150/thno.27941] evaluated the long-term effects of FUS on brain parenchyma in aged mice with Alzheimer's disease. This is the first study which applied a multimodal analysis to demonstrate the safety of FUS in aged brain in view of a potential introduction of this technique in common clinical practice in the future.
摘要
聚焦超声（FUS）作为一种血脑屏障（BBB）通透性增强工具，为治疗多种疾病开辟了新途径，特别是脑肿瘤和神经退行性疾病。然而，即使在这些领域有很有前途的结果，该技术的疗效和安全性在长期随访中仍然未知。Blackmore 等人的研究[Theranostics 2018; 8(22):6233-6247. doi:10.7150/thno.27941]评估了 FUS 对老年阿尔茨海默病小鼠脑实质的长期影响。这是第一项应用多模态分析来证明 FUS 在老年大脑中安全性的研究，以期在未来将该技术引入常规临床实践。
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