School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, QLD, Australia.
The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, QLD, Australia.
J Physiol. 2019 Apr;597(8):2177-2184. doi: 10.1113/JP277648. Epub 2019 Mar 20.
Physical activity is associated with reduced mortality rates for survivors of colorectal cancer. Acute high intensity interval exercise (HIIE) reduced colon cancer cell number in vitro and promoted increases in inflammatory cytokines immediately following exercise. This acute suppression of colon cancer cell number was transient and not observed at 120 minutes post-acute HIIE. The acute effects of exercise may constitute an important mechanism by which exercise can influence colorectal cancer outcomes.
Physical activity is associated with significant reductions in colorectal cancer mortality. However, the mechanisms by which exercise mediates this anti-oncogenic effect are not clear. In the present study, colorectal cancer survivors completed acute (n = 10) or chronic (n = 10) exercise regimes. An acute high intensity interval exercise session (HIIE; 4 × 4 min at 85-95% peak heart rate) was completed with serum samples collected at baseline, as well as 0 and 120 min post-exercise. For the 'chronic' intervention, resting serum was sampled before and after 4 weeks (12 sessions) of HIIE. The effect of serum on colon cancer cell growth was evaluated by incubating cells (CaCo-2 and LoVo) for up to 72 h and assessing cell number. Serum obtained immediately following HIIE, but not 120 min post-HIIE, significantly reduced colon cancer cell number. Significant increases in serum interleukin-6 (P = 0.023), interleukin-8 (P = 0.036) and tumour necrosis factor-α (P = 0.003) were found immediately following acute HIIE. At rest, short-term HIIE training did not promote any changes in cellular growth or cytokine concentrations. The acute effects of HIIE and the cytokine flux may be important mediators of reducing colon cancer cell progression. Repetitive exposure to these acute effects may contribute to the relationship between exercise and improved colorectal cancer survival.
身体活动与结直肠癌幸存者的死亡率降低有关。急性高强度间歇运动（HIIE）可减少体外结肠癌细胞数量，并在运动后立即促进炎症细胞因子的增加。这种结肠癌细胞数量的急性抑制是短暂的，在急性 HIIE 后 120 分钟时观察不到。运动的急性效应可能构成运动影响结直肠癌结果的重要机制。
身体活动与结直肠癌死亡率的显著降低有关。然而，运动介导这种抗癌作用的机制尚不清楚。在本研究中，结直肠癌幸存者完成了急性（n=10）或慢性（n=10）运动方案。进行了一次急性高强度间歇运动（HIIE；4×4 分钟，心率达到 85-95%峰值），在基线以及运动后 0 和 120 分钟采集血清样本。对于“慢性”干预，在 HIIE 后 4 周（12 次）前后采集静息血清样本。通过孵育细胞（CaCo-2 和 LoVo）长达 72 小时并评估细胞数量来评估血清对结肠癌细胞生长的影响。HIIE 后立即获得的血清，但不是 HIIE 后 120 分钟的血清，显著降低了结肠癌细胞数量。HIIE 后立即发现血清白细胞介素-6（P=0.023）、白细胞介素-8（P=0.036）和肿瘤坏死因子-α（P=0.003）显著增加。在休息时，短期 HIIE 训练不会促进细胞生长或细胞因子浓度的任何变化。HIIE 的急性效应和细胞因子通量可能是减少结肠癌细胞进展的重要介质。反复暴露于这些急性效应可能有助于解释运动与改善结直肠癌生存之间的关系。
