Thematic Task Force on Healthy Aging, CUECH Research Network, Universidad de Talca, Talca 3460000, Chile.
Interdisciplinary Center on Aging, Thrombosis Research Center, Department of Clinical Biochemistry and Immunohematology, Faculty of Health Sciences, Universidad de Talca, Talca 3460000, Chile.
Nutrients. 2019 Feb 22;11(2):456. doi: 10.3390/nu11020456.
We examined the ability of tomato pomace extract (by-product) to affect platelet aggregation in healthy humans (clinical pilot study). In phase 1 the tolerance of participants ( = 15; 5 per dose level) ingesting tomato pomace extract across three dose levels (1, 2.5, and 10 g) was evaluated. Phase 2 was a single-blind, placebo-controlled, parallel design human (male, = 99; 33 per group) pilot intervention trial investigating the acute and repeated dose effects (5 days) of different doses of tomato pomace extract (1 g, 2.5 g or placebo) on platelet aggregation ex vivo. Various flavonoids (coumaric acid, floridzin, floretin, procyanidin B₂, luteolin-7--glucoside, kaempferol, and quercitin) and nucleosides (adenosine, inosine, and guanosine) were identified in the tomato pomace extract. The clinical study showed that the daily consumption of 1 g of aqueous extract of tomato pomace for 5 days exerted an inhibitory activity on platelet aggregation.
我们研究了番茄渣提取物（副产物）对健康人体血小板聚集的影响（临床初步研究）。在第 1 阶段，我们评估了 15 名参与者（每个剂量水平 5 名）摄入番茄渣提取物三种剂量水平（1、2.5 和 10 克）的耐受性。第 2 阶段是一项单盲、安慰剂对照、平行设计的人体（男性，每组 33 名，共 99 名）初步干预试验，研究了不同剂量（1 克、2.5 克或安慰剂）的番茄渣提取物对血小板聚集的急性和重复剂量（5 天）影响。在番茄渣提取物中鉴定出了各种类黄酮（咖啡酸、根皮苷、芹菜素、原花青素 B₂、木樨草素-7--葡萄糖苷、山奈酚和槲皮素）和核苷（腺苷、肌苷和鸟苷）。临床研究表明，连续 5 天每天摄入 1 克番茄渣水提物可抑制血小板聚集。
