Eizadi-Mood Nastaran, Mahvari Razieh, Akafzadeh Savari Mahsa, Mohammadbeigi Ehsan, Feizi Awat, Mirmoghtadaei Parisa, Sami Ramin, Meamar Rokhsareh
Department of Clinical Toxicology, School of Medicine, Isfahan Clinical Toxicology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Isfahan Clinical Toxicology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
SAGE Open Med. 2023 Feb 7;11:20503121221147352. doi: 10.1177/20503121221147352. eCollection 2023.
Intoxication with pesticides is a well-known public health problem. We aimed to describe the demographic and toxico-clinical characteristics and outcomes of patients with pesticide poisoning.
This retrospective cross-sectional study was performed in Khorshid Hospital affiliated with Isfahan University of Medical Sciences, Isfahan, Iran. All patients with pesticide poisoning (insecticides, herbicides, fungicides, rodenticides, and acaricides) were evaluated. The patients' demographic, toxicological, clinical, and laboratory findings from March 2016 until March 2021 were collected and analyzed.
During the study period, 25,659 patients with acute poisoning were admitted, of which, 1567 (6.1% of the total poisoning) with pesticide poisoning were included. The mean ± SD age of the patients was 31.34 ± 13.7 years and 55.3% were men (male/female ratio = 1.23). In approximately 75% of the patients, poisoning occurred by suicidal attempts, while in 14.3% ( = 224), it was accidental. Insecticides caused about 51.30% of the poisonings. However, rodenticides were most commonly used in completed suicide attempts (79.9%). The frequency of previously attempted suicide, and self-harming was different among the patients with respect to the type of pesticide poisoning ( < 0.05). Previous suicidal attempts (35.3%) and self-harming (17.3%) were reported more in patients poisoned with the combination of pesticides. Half of the patients were employed. Nausea and vomiting (56.7%, = 889) were the most common clinical manifestations; 8.3% ( = 130) of the patients died, 64 of whom had rodenticide poisoning.
The prevalence of pesticide poisoning was relatively low; most were insecticide poisoning. Poisoning occurred most through attempted suicide. Rodenticides and herbicides had higher mortality rates than other pesticides. Patients with previously attempted suicide and self-harming behavior may use a combination of pesticides.
农药中毒是一个众所周知的公共卫生问题。我们旨在描述农药中毒患者的人口统计学、毒理临床特征及预后。
本回顾性横断面研究在伊朗伊斯法罕伊斯法罕医科大学附属霍希德医院进行。对所有农药中毒（杀虫剂、除草剂、杀菌剂、杀鼠剂和杀螨剂）患者进行评估。收集并分析了2016年3月至2021年3月期间患者的人口统计学、毒理学、临床和实验室检查结果。
研究期间，共收治25659例急性中毒患者，其中1567例（占总中毒人数的6.1%）为农药中毒患者。患者的平均年龄±标准差为31.34±13.7岁，男性占55.3%（男女比例=1.23）。约75%的患者中毒是自杀企图所致，而14.3%（=224例）是意外中毒。杀虫剂导致约51.30%的中毒事件。然而，杀鼠剂在自杀既遂案例中使用最为普遍（79.9%）。就农药中毒类型而言，既往自杀未遂和自我伤害的频率在患者中存在差异（<0.05）。既往有自杀未遂（35.3%）和自我伤害（17.3%）的情况在农药混合中毒患者中报告较多。一半的患者有工作。恶心和呕吐（56.7%，=889例）是最常见的临床表现；8.3%（=130例）的患者死亡，其中64例为杀鼠剂中毒。
农药中毒的患病率相对较低；多数为杀虫剂中毒。中毒大多是自杀企图所致。杀鼠剂和除草剂的死亡率高于其他农药。既往有自杀未遂和自我伤害行为的患者可能会混合使用农药。
