Department of Public Health, Environments and Society, London School of Hygiene & Tropical Medicine, London, UK.
Institute of Environmental Assessment and Water Research (IDAEA), Spanish Council for Scientific Research (CSIC), Barcelona, Spain.
Int J Epidemiol. 2019 Aug 1;48(4):1101-1112. doi: 10.1093/ije/dyz008.
The health burden associated with temperature is expected to increase due to a warming climate. Populations living in cities are likely to be particularly at risk, but the role of urban characteristics in modifying the direct effects of temperature on health is still unclear. In this contribution, we used a multi-country dataset to study effect modification of temperature-mortality relationships by a range of city-specific indicators.
We collected ambient temperature and mortality daily time-series data for 340 cities in 22 countries, in periods between 1985 and 2014. Standardized measures of demographic, socio-economic, infrastructural and environmental indicators were derived from the Organisation for Economic Co-operation and Development (OECD) Regional and Metropolitan Database. We used distributed lag non-linear and multivariate meta-regression models to estimate fractions of mortality attributable to heat and cold (AF%) in each city, and to evaluate the effect modification of each indicator across cities.
Heat- and cold-related deaths amounted to 0.54% (95% confidence interval: 0.49 to 0.58%) and 6.05% (5.59 to 6.36%) of total deaths, respectively. Several city indicators modify the effect of heat, with a higher mortality impact associated with increases in population density, fine particles (PM2.5), gross domestic product (GDP) and Gini index (a measure of income inequality), whereas higher levels of green spaces were linked with a decreased effect of heat.
This represents the largest study to date assessing the effect modification of temperature-mortality relationships. Evidence from this study can inform public-health interventions and urban planning under various climate-change and urban-development scenarios.
由于气候变暖,与温度相关的健康负担预计将会增加。生活在城市中的人群可能尤其面临风险,但城市特征在改变温度对健康的直接影响方面的作用仍不清楚。在本研究中,我们使用多国家数据集研究了一系列特定于城市的指标对温度-死亡率关系的效应修饰作用。
我们收集了 22 个国家 340 个城市 1985 年至 2014 年期间的环境温度和每日死亡率时间序列数据。人口统计学、社会经济、基础设施和环境指标的标准化措施源自经济合作与发展组织(OECD)的区域和大都市数据库。我们使用分布式滞后非线性和多变量荟萃回归模型来估计每个城市的热和冷相关死亡率的归因分数(AF%),并评估每个城市指标的效应修饰作用。
热相关和冷相关死亡分别占总死亡人数的 0.54%(95%置信区间:0.49%至 0.58%)和 6.05%(5.59%至 6.36%)。一些城市指标修饰了热的影响,人口密度、细颗粒物(PM2.5)、国内生产总值(GDP)和基尼指数(衡量收入不平等的指标)的增加与更高的死亡率相关,而更高水平的绿地与热效应的降低有关。
这是迄今为止评估温度-死亡率关系的效应修饰作用的最大研究。本研究的证据可以为各种气候变化和城市发展情景下的公共卫生干预和城市规划提供信息。