Guo Chuan, Li Shen, Rao Xiang-Rong
Department of Nephrology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, China.
Chin J Integr Med. 2019 Mar;25(3):163-167. doi: 10.1007/s11655-019-3065-z. Epub 2019 Feb 28.
Chronic kidney disease (CKD) is a clinical syndrome with a series of clinical manifestations and metabolic disorders caused by many diseases, which are characterized by progressive deterioration or irreversible damage of renal structures and functions. With the progress of epidemiological research, CKD has brought about huge economic and psychological burdens. There is a considerable risk of cardiovascular events or death than progression to end-stage renal disease for patients. Particular attentions should be paid to the new goals of reducing cardiovascular events and all-cause mortality. It is important to analyze the etiology and pathogenesis according to patients' ages, regions, primary disease as well as different stages of disease, and choose the appropriate therapeutic strategies accordingly. In clinical practice, due to the uncertainty of therapeutic effects of modern medicine based on the risk factors, it is necessary to use Chinese medicine (CM) to delay the disease progression and reduce comorbidities. Turbid toxin and blood stasis are two critical pathological factors worthy of concerns in the theory of CM. In addition, appropriate use of CM may help improve the quality of life of patients with CKD.
慢性肾脏病（CKD）是一种由多种疾病引起的、具有一系列临床表现和代谢紊乱的临床综合征，其特征为肾脏结构和功能进行性恶化或不可逆转的损害。随着流行病学研究的进展，CKD带来了巨大的经济和心理负担。对于患者而言，发生心血管事件或死亡的风险比进展至终末期肾病的风险更大。应特别关注降低心血管事件和全因死亡率的新目标。根据患者的年龄、地区、原发疾病以及疾病的不同阶段分析病因和发病机制，并据此选择合适的治疗策略非常重要。在临床实践中，由于基于风险因素的现代医学治疗效果存在不确定性，有必要运用中医药来延缓疾病进展并减少合并症。浊毒和血瘀是中医理论中两个值得关注的关键病理因素。此外，合理运用中医药可能有助于提高CKD患者的生活质量。
