Simpson Querrey Institute, Northwestern University, Chicago, IL 60611, USA.
Department of Electrical Engineering and Computer Science, Northwestern University, Evanston, IL 60208, USA.
Science. 2019 Mar 1;363(6430). doi: 10.1126/science.aau0780.
Existing vital sign monitoring systems in the neonatal intensive care unit (NICU) require multiple wires connected to rigid sensors with strongly adherent interfaces to the skin. We introduce a pair of ultrathin, soft, skin-like electronic devices whose coordinated, wireless operation reproduces the functionality of these traditional technologies but bypasses their intrinsic limitations. The enabling advances in engineering science include designs that support wireless, battery-free operation; real-time, in-sensor data analytics; time-synchronized, continuous data streaming; soft mechanics and gentle adhesive interfaces to the skin; and compatibility with visual inspection and with medical imaging techniques used in the NICU. Preliminary studies on neonates admitted to operating NICUs demonstrate performance comparable to the most advanced clinical-standard monitoring systems.
现有的新生儿重症监护病房(NICU)生命体征监测系统需要将多个电线连接到刚性传感器上,这些传感器与皮肤具有强粘性的接口。我们引入了一对超薄、柔软、类似皮肤的电子设备,它们的协调、无线操作复制了这些传统技术的功能,但规避了它们固有的局限性。工程科学方面的推动因素包括支持无线、无电池操作的设计;实时、传感器内数据分析;时间同步、连续数据流;与皮肤的柔软力学和温和粘性接口;以及与视觉检查和 NICU 中使用的医学成像技术的兼容性。在被送入正在运行的 NICU 的新生儿身上进行的初步研究表明,其性能可与最先进的临床标准监测系统相媲美。