各种神经系统疾病患者脑脊液中促甲状腺激素释放激素水平

Thyrotropin releasing hormone levels in human cerebrospinal fluid in various neurologic diseases.

作者信息

Mitsuma T, Nogimori T, Sahashi K, Adachi K, Kihara M, Murakami K, Nakao N, Gonda M, Fujii K, Okabe Y

出版信息

Am J Med Sci. 1986 Mar;291(3):164-7. doi: 10.1097/00000441-198603000-00004.

DOI:10.1097/00000441-198603000-00004

Abstract

Thyrotropin releasing hormone (TRH) in the human cerebrospinal fluid (CSF) of 102 patients with non-neurologic and neurologic diseases was measured by a specific TRH radioimmunoassay. TRH levels in CSF were 17.6 +/- 3.4 pg/ml (mean +/- SE) in non-neurologic diseases. TRH levels in CSF were significantly elevated in cases of spinal cord tumor and multiple sclerosis (acute phase). Elevated TRH levels in CSF were decreased in these diseases by operation or prednisolone treatment, respectively. From these data, it is suggested that TRH is present in the human CSF and that measurement of TRH levels in CSF may be a useful indicator of the activity of certain neurologic diseases.

摘要

采用特异性促甲状腺激素释放激素（TRH）放射免疫分析法，对102例非神经系统疾病和神经系统疾病患者的人脑脊液（CSF）中的TRH进行了测定。非神经系统疾病患者脑脊液中的TRH水平为17.6±3.4 pg/ml（均值±标准误）。脊髓肿瘤和多发性硬化（急性期）患者脑脊液中的TRH水平显著升高。在这些疾病中，通过手术或泼尼松龙治疗，脑脊液中升高的TRH水平分别降低。根据这些数据，提示TRH存在于人脑脊液中，脑脊液中TRH水平的测定可能是某些神经系统疾病活动的有用指标。