a School of Pharmacy , Anhui University of Chinese Medicine , Hefei , P. R. China.
b Synergetic Innovation Center of Anhui Authentic Chinese Medicine Quality Improvement , Hefei , P. R. China.
Nat Prod Res. 2019 Aug;33(15):2133-2138. doi: 10.1080/14786419.2018.1488706. Epub 2018 Dec 22.
A new steroid lactone aspergilolide (), and nine known compounds helvolic acid (), verruculogen (), tryprostatin B (), 13-oxofumitremorgin B (), fumitremorgin C (), demethoxy fumitremorgin C (), terezine D (), aszonalenin (), 12, 13-dihydroxy-fumitremorgin C () from cultures of the endophytic fungus . MBL1612. Their chemical structures were determined by a series of extensive spectroscopic methods. All of the compounds were isolated from this genus for the first time. The cytotoxicity against five human cancer cell lines of new compound were detected.
一种新的甾体内酯aspergilolide ()，以及从内生真菌. MBL1612 的培养物中分离得到的 9 种已知化合物：helvolic acid ()、verruculogen ()、tryprostatin B ()、13-oxofumitremorgin B ()、fumitremorgin C ()、demethoxy fumitremorgin C ()、terezine D ()、aszonalenin ()、12,13-二羟基-fumitremorgin C ()。其化学结构通过一系列广泛的光谱方法确定。所有化合物均为首次从该属中分离得到。新化合物对 5 个人类癌细胞系的细胞毒性进行了检测。
