Askanazi J, Hensle T W, Starker P M, Lockhart S H, LaSala P A, Olsson C, Kinney J M
Ann Surg. 1986 Mar;203(3):236-9. doi: 10.1097/00000658-198603000-00002.
This study is a retrospective review of the effect of nutritional support on duration of hospitalization in patients undergoing radical cystectomy. Thirty-five patients were randomly assigned to receive either 5% dextrose (D5W) solution plus electrolytes or total parenteral nutrition (TPN) following operation. The assigned nutritional regimen was continued for 1 week after operation until oral intake resumed. If the patients receiving D5W remained incapable of oral intake after 1 week, TPN was instituted. The group receiving immediate postoperative TPN had a median duration of hospitalization of 17 days, while the median duration for the group receiving 5% dextrose solution was 24 days. All other patient characteristics, such as age, sex, stage/grade of tumor, and extent of preoperative radiotherapy, were similar in the two groups. These results demonstrate that immediate postoperative institution of nutritional support reduced hospitalization time following radical cystectomy. This indicates that the routine use of 5% dextrose as postoperative nutrition should be reevaluated.
本研究是一项关于营养支持对接受根治性膀胱切除术患者住院时间影响的回顾性研究。35例患者术后被随机分配接受5%葡萄糖(D5W)溶液加电解质或全胃肠外营养(TPN)。指定的营养方案在术后持续1周,直至恢复经口摄入。如果接受D5W的患者在1周后仍无法经口摄入,则开始给予TPN。术后立即接受TPN的组中位住院时间为17天,而接受5%葡萄糖溶液组的中位住院时间为24天。两组的所有其他患者特征,如年龄、性别、肿瘤分期/分级和术前放疗范围,均相似。这些结果表明,术后立即给予营养支持可缩短根治性膀胱切除术后的住院时间。这表明应重新评估将5%葡萄糖作为术后营养的常规使用。