大鼠肝癌中丝氨酸代谢的酶失衡
Enzymic imbalance in serine metabolism in rat hepatomas.
作者信息
Snell K, Weber G
出版信息
Biochem J. 1986 Jan 15;233(2):617-20. doi: 10.1042/bj2330617.
Abstract
The activity of 3-phosphoglycerate dehydrogenase was high in tissues of high cell-renewal capacity, and was increased in neonatal and regenerating liver and, more markedly, in hepatomas. Serine hydroxymethyltransferase activity was present in hepatomas, whereas other enzymes of serine utilization (serine dehydratase and serine aminotransferase) were absent. This enzymic imbalance couples serine biosynthesis preferentially to nucleotide precursor formation in cancer cells.
摘要
3-磷酸甘油酸脱氢酶的活性在细胞更新能力高的组织中较高，在新生肝脏和再生肝脏中增加，在肝癌中增加更为明显。丝氨酸羟甲基转移酶活性在肝癌中存在，而其他丝氨酸利用酶（丝氨酸脱水酶和丝氨酸转氨酶）则不存在。这种酶的失衡使癌细胞中的丝氨酸生物合成优先与核苷酸前体形成相关联。
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