Suteanu S, Moanga M, Stefanesco D T, Bancou A, Dragomir C T, Pirvu-Blaja V, Rindasu G
Rev Rhum Mal Osteoartic. 1978 Jun;45(6):395-9.
The responsiveness to mitogens of the in vitro cultural peripheral blood lymphocytes from 60 patients with rheumatoid arthritis (RA) and from controls was evaluated in terms of H3 TdR uptake. The size of the response was tested for a correlation with the percentages of T and B lymphocytes, determined by E and EAC rosette test, as well as with the various alterations of the clinical and biological parameters. In the RA cultures an elevated level of spontaneous H3 TdR uptake was found, which could be an in vitro carry-over of an activation in vivo. No significant statistical differences were found between rheumatic and control groups as regards: 1 degrees--the H3 TdR uptake induced both by PHA and SLO; 2 degrees--the proportion of the circulating T and B lymphocytes. The only positive correlation evidenced by this study in RA patients was that between the proportion of B lymphocytes and the gammaglobulin level in the plasma.
通过³H-胸腺嘧啶核苷（³H-TdR）摄取量评估了60例类风湿性关节炎（RA）患者及对照者的体外培养外周血淋巴细胞对丝裂原的反应性。检测了反应大小与通过E和EAC玫瑰花结试验确定的T和B淋巴细胞百分比以及临床和生物学参数的各种改变之间的相关性。在RA培养物中发现³H-TdR摄取的自发水平升高，这可能是体内激活状态在体外的延续。在以下方面，风湿组与对照组之间未发现显著统计学差异：1°——PHA和SLO诱导的³H-TdR摄取；2°——循环T和B淋巴细胞的比例。本研究在RA患者中唯一证实的正相关是B淋巴细胞比例与血浆中γ球蛋白水平之间的相关性。
