105 Military Hospital with Outpatient Clinic in Zary, Domanskiego 2, 68-200 Zary, Poland.
Department of Nephrology, Hypertension and Family Medicine, WAM Teaching Hospital of Lodz, Zeromskiego 113, Lodz, 90-549, Poland.
Curr Pharm Des. 2020;26(27):3341-3348. doi: 10.2174/1381612825666190227224246.
Diabetes mellitus (DM) due to its increasing prevalence and associated morbidity and mortality has become a serious public health problem. In DM, HDL may lose its beneficial features and become proatherogenic due to its altered biological activity thus increasing cardiovascular risk. The aim of this study was to assess the influence of the presence of diabetes mellitus type 2 and its duration on the distribution of HDL subfractions. Moreover, the effect of statin treatment on HDL subfraction share was analysed in this study.
The study group consisted of 50 patients with newly diagnosed DM and 50 persons with DM for longer than 10 years while the control group consisted of 50 healthy volunteers. HDL subfractions were analysed with the use of Lipoprint.
We demonstrated progressive worsening of heart functioning and impairment of its structure in the course of diabetes mellitus. Moreover, we observed that HDL-6 subfraction and intermediate HDL fraction are lowest in the group with advanced DMt2 compared to the group with newly diagnosed DM and a healthy control group. Finally, the results of our study indicated the effect of statin treatment on HDL subfractions that seems not to be advantageous.
It seems that in patients with diabetes mellitus compromised antiatherogenic properties of HDL, as a result of oxidative modification and glycation of the HDL protein as well as the transformation of the HDL proteome into a proinflammatory protein, increase cardiovascular risk.
由于糖尿病（DM）的患病率不断增加，以及与之相关的发病率和死亡率，它已成为一个严重的公共卫生问题。在糖尿病中，由于其生物活性发生改变，HDL 可能会失去其有益特性，并变得促动脉粥样硬化，从而增加心血管风险。本研究旨在评估 2 型糖尿病的存在及其持续时间对 HDL 亚组分分布的影响。此外，本研究还分析了他汀类药物治疗对 HDL 亚组分的影响。
研究组包括 50 例新诊断的糖尿病患者和 50 例糖尿病病程超过 10 年的患者，对照组包括 50 例健康志愿者。使用 Lipoprint 分析 HDL 亚组分。
我们发现随着糖尿病的进展，心脏功能逐渐恶化，结构受损。此外，我们观察到与新诊断的 DM 组和健康对照组相比，在病程较长的 2 型糖尿病组中，HDL-6 亚组分和中间 HDL 亚组分最低。最后，我们的研究结果表明他汀类药物治疗对 HDL 亚组分的影响似乎没有优势。
似乎在糖尿病患者中，HDL 的抗动脉粥样硬化特性受损，这是由于 HDL 蛋白的氧化修饰和糖化以及 HDL 蛋白质组转化为促炎蛋白所致，从而增加了心血管风险。
