ELKH-DE Public Health Research Group, University of Debrecen, Debrecen, 4028, Hungary.
Department of Health Methodology and Public Health, Faculty of Health, University of Debrecen, Nyíregyháza, 4400, Hungary.
Sci Rep. 2022 Jun 28;12(1):10915. doi: 10.1038/s41598-022-15192-9.
High-density lipoprotein cholesterol (HDL-C) is not a homogenous lipid fraction, but it can be further divided into subfractions. It is well-known that the Roma population has a high prevalence of reduced HDL-C levels and cardiovascular diseases (CVDs). However, it is unknown how this reduction affects different HDL subfractions, and whether changes in their quantity/representation are associated with an increased cardiovascular risk among them. In the present study, the HDL subfraction profile of the Hungarian general (HG) and the Roma populations were compared, and the subfractions showing a significant difference between the two populations were identified. The association of HDL subfractions with CVD risk estimated by the Framingham risk score (FRS) and the Systematic COronary Risk Evaluation (SCORE) algorithms were also defined. The present study is the first to find a significant association between HDL subfractions and cardiovascular risk estimated by FRS and SCORE. Ten HDL subfractions were investigated on small but carefully selected samples comprising 100 control subjects (with normal lipid profile) and 277 case subjects (with reduced HDL-C levels) from HG and Roma populations of a complex health survey. The level of HDL-1 to 3 subfractions and HDL-L showed a significant inverse association with cardiovascular risk estimated by both SCORE and FRS algorithms, whereas HDL-4 to 6 and HDL-I only for FRS. A higher representation (in %) of HDL-1 to 3 has a significant risk-reducing effect, while HDL-8 to 10 has a risk-increasing effect estimated by FRS. Our results confirmed that reduced levels of HDL-6 and -7 expressed in mmol/L were significantly associated with Roma ethnicity.
高密度脂蛋白胆固醇（HDL-C）不是均匀的脂质部分，但它可以进一步分为亚组分。众所周知，罗姆人族群的 HDL-C 水平和心血管疾病（CVD）的患病率较高。然而，尚不清楚这种降低如何影响不同的 HDL 亚组分，以及它们的数量/表现的变化是否与其中的心血管风险增加有关。在本研究中，比较了匈牙利普通人群（HG）和罗姆人群的 HDL 亚组分谱，并确定了两个人群之间存在显著差异的亚组分。还确定了 HDL 亚组分与Framingham 风险评分（FRS）和系统性冠状动脉风险评估（SCORE）算法估计的 CVD 风险之间的关联。本研究首次发现 HDL 亚组分与 FRS 和 SCORE 估计的心血管风险之间存在显著关联。在一项小型但精心挑选的研究中，对来自 HG 和罗姆人群的 100 名对照受试者（血脂谱正常）和 277 名病例受试者（HDL-C 水平降低）的 10 种 HDL 亚组分进行了研究。HDL-1 至 3 亚组分和 HDL-L 的水平与 SCORE 和 FRS 算法估计的心血管风险呈显著负相关，而 HDL-4 至 6 和 HDL-I 仅与 FRS 相关。HDL-1 至 3 的代表（以%表示）较高具有显著的降低风险作用，而 HDL-8 至 10 具有 FRS 估计的增加风险作用。我们的结果证实，以 mmol/L 表示的 HDL-6 和 -7 水平降低与罗姆族裔显著相关。
