Department of Neurosurgery, Cancer Center Amsterdam, Brain Tumor Center Amsterdam, Amsterdam UMC, VU University Medical Center, Amsterdam, The Netherlands.
Blood. 2019 May 30;133(22):2359-2364. doi: 10.1182/blood-2018-12-852830. Epub 2019 Mar 4.
Liquid biopsies have been considered the holy grail in achieving effective cancer management, with blood tests offering a minimally invasive, safe, and sensitive alternative or complementary approach for tissue biopsies. Currently, blood-based liquid biopsy measurements focus on the evaluation of biomarker types, including circulating tumor DNA, circulating tumor cells, extracellular vesicles (exosomes and oncosomes), and tumor-educated platelets (TEPs). Despite the potential of individual techniques, each has its own advantages and disadvantages. Here, we provide further insight into TEPs.
液体活检被认为是实现有效癌症管理的圣杯，血液检测为组织活检提供了一种微创、安全和敏感的替代或补充方法。目前，基于血液的液体活检测量侧重于评估生物标志物类型，包括循环肿瘤 DNA、循环肿瘤细胞、细胞外囊泡（外泌体和肿瘤囊泡）和肿瘤诱导的血小板（TEP）。尽管每种技术都有其潜在的优势，但也都有其自身的优点和缺点。在这里，我们进一步探讨了 TEP。
