可切除宫颈癌中全身炎症反应（SIR）参数的预后价值
Prognostic Values of Systemic Inflammation Response (SIR) Parameters in Resectable Cervical Cancer.
作者信息
Wang Wen-Jie, Li Ying, Zhu Jie, Gao Min-Jie, Shi Jian-Ping, Huang Yue-Qing
机构信息
Department of Radio-Oncology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu, People's Republic of China.
Department of General Practice, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu, People's Republic of China.
出版信息
Dose Response. 2019 Feb 26;17(1):1559325819829543. doi: 10.1177/1559325819829543. eCollection 2019 Jan-Mar.
BACKGROUND
Cervical carcinoma is the leading cause of cancer mortality in women. C-reactive protein (CRP), albumin (ALB), globulin (GLB), lactate dehydrogenase (LDH), and albumin-to-globulin ratio (AGR) are indicators of systemic inflammation response correlated with tumor outcomes.
METHODS
This study recruited 110 patients with cervical cancer. The patients were divided into 2 groups according to pretreatment median values of CRP, ALB, GLB, LDH, and AGR. The post/preradiotherapy or post/pretreatment ratios were defined as rates of pretreatment CRP, ALB, GLB, LDH, and AGR values and the corresponding ones obtained after radiotherapy or whole treatment.
RESULTS
Higher pretreatment CRP or LDH levels were correlated with worse progression-free survival (PFS) and overall survival (OS). Increased post/preradiotherapy CRP ratio was correlated with worse PFS and OS, increased post/preradiotherapy LDH ratio was correlated with worse PFS. Increased post/pretreatment CRP ratio was correlated with worse PFS and OS, not-increased post/pretreatment AGR ratio was correlated with worse OS. Cox regression analysis model indicated that, moderately or poorly of differentiation, higher pretreatment CRP or LDH levels were independently associated with worse PFS, higher pretreatment CRP or LDH levels and increased post/pretreatment CRP ratio were independently associated with worse OS.
CONCLUSION
CRP, LDH, or AGR are correlated with outcomes of resectable cervical cancer.
背景
宫颈癌是女性癌症死亡的主要原因。C反应蛋白（CRP）、白蛋白（ALB）、球蛋白（GLB）、乳酸脱氢酶（LDH）以及白蛋白与球蛋白比值（AGR）是与肿瘤预后相关的全身炎症反应指标。
方法
本研究招募了110例宫颈癌患者。根据CRP、ALB、GLB、LDH和AGR的预处理中位数将患者分为两组。放疗后/放疗前或治疗后/治疗前的比值定义为放疗前CRP、ALB、GLB、LDH和AGR值与放疗或整个治疗后获得的相应值的比率。
结果
较高的预处理CRP或LDH水平与较差的无进展生存期（PFS）和总生存期（OS）相关。放疗后/放疗前CRP比值升高与较差的PFS和OS相关，放疗后/放疗前LDH比值升高与较差的PFS相关。治疗后/治疗前CRP比值升高与较差的PFS和OS相关，治疗后/治疗前AGR比值未升高与较差的OS相关。Cox回归分析模型表明，分化程度中等或较差、预处理CRP或LDH水平较高与较差的PFS独立相关，预处理CRP或LDH水平较高以及治疗后/治疗前CRP比值升高与较差的OS独立相关。
结论
CRP、LDH或AGR与可切除宫颈癌的预后相关。
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