保加利亚的戊型肝炎病毒感染：该国情况简要分析
Hepatitis E Virus Infection in Bulgaria: A Brief Analysis of the Situation in the Country.
作者信息
Baymakova Magdalena, Popov Georgi T, Pepovich Roman, Tsachev Ilia
机构信息
Department of Infectious Diseases, Military Medical Academy, Sofia, Bulgaria.
Department of Infectious Pathology, Hygiene, Technology and Control of Foods from Animal Origin, Faculty of Veterinary Medicine, University of Forestry, Sofia, Bulgaria.
出版信息
Open Access Maced J Med Sci. 2019 Jan 25;7(3):458-460. doi: 10.3889/oamjms.2019.073. eCollection 2019 Feb 15.
BACKGROUND
Over the past two decades, more thorough investigations for hepatitis E virus (HEV) infection have been done in the world. Reports from Southeast European countries have increased.
AIM
The current article presents a critical analysis of all studies for HEV in Bulgaria.
MATERIAL AND METHODS
A literature search was done using available medical databases. We analysed the literature in PubMed databases and Bulgarian medical databases for English and Bulgarian languages sources. Preference was given to the sources published within the past 24 years (January 1995 - September 2018).
RESULTS
Two thousand two hundred and fifty-seven blood serums were tested for the analysed period (1995 - 2018), and 13.1% of them were positive for acute HEV (Mean ± SD: 20.38 ± 25.77%; 95% CI: 1.29 - 39.47%). The following subtypes were established in the country - HEV Subtype 3e, HEV Subtype 3f, HEV Subtype 3c, HEV Subtype 3i, HEV Subtype 3hi and HEV Subtype 1.
CONCLUSION
We hope that the National Health Organizations will take adequate and timely measures to increase the knowledge and research for HEV among Bulgarian citizens.
背景
在过去二十年里，全球对戊型肝炎病毒（HEV）感染进行了更全面的调查。来自东南欧国家的报告有所增加。
目的
本文对保加利亚所有关于HEV的研究进行批判性分析。
材料与方法
利用现有的医学数据库进行文献检索。我们分析了PubMed数据库以及保加利亚医学数据库中英语和保加利亚语来源的文献。优先选择过去24年（1995年1月至2018年9月）发表的文献。
结果
在分析期间（1995 - 2018年）对2257份血清进行了检测，其中13.1%的血清急性戊型肝炎病毒检测呈阳性（均值±标准差：20.38 ± 25.77%；95%置信区间：1.29 - 39.47%）。该国确定了以下亚型——戊型肝炎病毒3e亚型、戊型肝炎病毒3f亚型、戊型肝炎病毒3c亚型、戊型肝炎病毒3i亚型、戊型肝炎病毒3hi亚型和戊型肝炎病毒1型。
结论
我们希望国家卫生组织将采取充分及时的措施，以增加保加利亚公民对戊型肝炎病毒的认识和研究。
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