Kinimi Edson, Shayo Mariana J, Patrick Bisimwa N, Angwenyi Samuel O, Kasanga Christopher J, Weyer Jacqueline, Jansen van Vuren Petrus, Paweska Janusz T, Mboera Leonard E G, Misinzo Gerald
Department of Veterinary Microbiology, Parasitology and Biotechnology, College of Veterinary Medicine and Biomedical Sciences, Sokoine University of Agriculture, Morogoro, Tanzania.
Center for Emerging, Zoonotic and Parasitic Diseases, National Institute for Communicable Diseases of the National Health Laboratory Services, Sandringham, Republic of South Africa.
Infect Ecol Epidemiol. 2018 Dec 17;8(1):1553460. doi: 10.1080/20008686.2018.1553460. eCollection 2018.
: Chikungunya virus (CHIKV) infection is an emerging mosquito-borne disease that has been associated with frequent epidemics in the world. However, there is a dearth of information on its magnitude and associated risk factors in Tanzania. : A study was conducted to determine seroprevalence of CHIKV among febrile patients seeking medical care at health facilities in Karagwe, Sengerema, Kilombero and Kyela districts. : Structured questionnaires were administered and 728 serum samples were collected between May and June, 2015 and tested for the presence of CHIKV-IgM and IgG-specific antibodies using Enzyme-linked immunosorbent assay. : The common clinical characteristics exhibited by outpatients were fever, headache and joint pains (100%, 70%, and 68.3% respectively). Out of 728 outpatients screened for CHIKV, 105 (14%) tested CHIKV IgG positive whilst 11 (1.5%) tested CHIKV IgM positive. Chikungunya seropositivity was significantly higher than previously reported in Tanzania. The most affected age group was 20-29 years. Our results indicate that CHIKV infection is prevalent and contributes to the burden of febrile illnesses in Tanzania. The seroprevalence varies between districts, reflecting variation in mosquito vector transmission dynamics in different parts of the country. CHIKV: Chikungunya virus; EDTA: Ethylenediaminetetraacetic acid; ELISA: Enzyme-linked immunosorbent assay; IgG: Immunoglobulin G; IgM: Immunoglobulin M; NIMR: National Institute for Medical Research; RU: Relative Units; SACIDS: Southern African Centre for Infectious Disease Surveillance; USA: United States of America.
基孔肯雅病毒（CHIKV）感染是一种新出现的蚊媒疾病，在全球频繁引发疫情。然而，坦桑尼亚关于该疾病的规模及相关风险因素的信息匮乏。
开展了一项研究，以确定在卡拉圭、森盖雷马、基洛姆贝罗和凯拉地区医疗机构寻求医疗护理的发热患者中基孔肯雅病毒的血清阳性率。
采用了结构化问卷，并于2015年5月至6月期间收集了728份血清样本，使用酶联免疫吸附测定法检测基孔肯雅病毒IgM和IgG特异性抗体的存在情况。
门诊患者表现出的常见临床特征为发热、头痛和关节疼痛（分别为100%、70%和68.3%）。在728名接受基孔肯雅病毒筛查的门诊患者中，105人（14%）的基孔肯雅病毒IgG检测呈阳性，而11人（1.5%）的基孔肯雅病毒IgM检测呈阳性。基孔肯雅病毒血清阳性率显著高于坦桑尼亚此前报告的水平。受影响最严重的年龄组为20 - 29岁。我们的结果表明，基孔肯雅病毒感染在坦桑尼亚很普遍，且加重了发热疾病的负担。血清阳性率在不同地区有所差异，反映了该国不同地区蚊媒传播动态的变化。
基孔肯雅病毒；EDTA：乙二胺四乙酸；ELISA：酶联免疫吸附测定法；IgG：免疫球蛋白G；IgM：免疫球蛋白M；NIMR：国家医学研究所；RU：相对单位；SACIDS：南部非洲传染病监测中心；USA：美利坚合众国
