Ali Mude Abdirasak Sharif, Nageye Yahye Ahmed, Bello Kizito Eneye
Department of Microbiology and Laboratory Science, Faculty of Medicine and Health Sciences, SIMAD University, Mogadishu 252, Somalia.
Department of Microbiology, Faculty of Natural Science, Kogi State (Prince Abubakar Audu) University, Anyigba PMB 1008, Kogi State, Nigeria.
J Trop Med. 2024 Oct 25;2024:7357911. doi: 10.1155/2024/7357911. eCollection 2024.
The incidence of Chikungunya in tropical Africa is still of major epidemiological significance. This study aims to determine the prevalence of chikungunya in East Africa through a systematic review and meta-analysis of published studies. We conducted a comprehensive search across six electronic databases-Web of Science, PubMed, ScienceDirect, Scopus, and Google Scholar-using specific keywords to address the worldwide impact of chikungunya following the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines. A meta-analysis was performed on our eligible studies using the random effect model. Our search returned 40 eligible articles involving 4122 Chikungunya cases in 13 East African nations. These studies, conducted between 2014 and 2024 across 13 East African nations, provided diverse data on chikungunya prevalence. The overall pooled prevalence of chikungunya in East Africa was 20.6% (95% CI: 18.8%-22.5% and = 99.62%). Subgroup analyses revealed variations in prevalence across different countries, study designs, detection methods, and publication years. Notably, Rwanda and Djibouti exhibited high prevalence rates of 63.0% and 50.4%, respectively, while Kenya and Somalia reported a moderate prevalence of 12.2%. The detection methods also influenced prevalence rates, with RT-PCR studies indicating a higher prevalence (28.3%) compared to ELISA (19.3%). The study highlights the significant burden of chikungunya in East Africa, and the findings underscore the need for targeted public health interventions and improved surveillance to manage and control chikungunya outbreaks in the region.
基孔肯雅热在热带非洲的发病率仍然具有重大的流行病学意义。本研究旨在通过对已发表研究进行系统综述和荟萃分析，确定基孔肯雅热在东非的流行情况。我们按照系统综述和荟萃分析的首选报告项目（PRISMA）指南，使用特定关键词在六个电子数据库——科学网、PubMed、ScienceDirect、Scopus和谷歌学术上进行了全面搜索，以探讨基孔肯雅热的全球影响。对符合条件的研究采用随机效应模型进行荟萃分析。我们的搜索返回了40篇符合条件的文章，涉及东非13个国家的4122例基孔肯雅热病例。这些研究在2014年至2024年期间在东非13个国家开展，提供了关于基孔肯雅热流行情况的多样数据。东非基孔肯雅热的总体合并患病率为20.6%（95%置信区间：18.8%-22.5%，I² = 99.62%）。亚组分析显示，不同国家、研究设计、检测方法和发表年份的患病率存在差异。值得注意的是，卢旺达和吉布提的患病率分别高达63.0%和50.4%，而肯尼亚和索马里的患病率为中等水平，为12.2%。检测方法也影响患病率，逆转录聚合酶链反应（RT-PCR）研究显示患病率较高（28.3%），而酶联免疫吸附测定（ELISA）为19.3%。该研究凸显了基孔肯雅热在东非造成的重大负担，研究结果强调需要采取有针对性的公共卫生干预措施并加强监测，以管理和控制该地区的基孔肯雅热疫情。
