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乳酸菌治疗重度牙周炎和口臭的临床效果:一项双盲、安慰剂对照、随机临床试验。

Clinical effect of Lactobacillus on the treatment of severe periodontitis and halitosis: A double-blinded, placebo-controlled, randomized clinical trial.

作者信息

Soares Léo Guimarães, Carvalho Elisa Barcelos de, Tinoco Eduardo Muniz Barretto

机构信息

Department of Periodontology, University of Rio de Janeiro, Brazil,

Department of Functional Nutrition, NutConsult, Rio de Janeiro, Brazil.

出版信息

Am J Dent. 2019 Feb;32(1):9-13.

PMID:30834725
Abstract

PURPOSE

To evaluate the clinical association between Lactobacillus and the efficacy of adjuvant treatment of severe periodontitis, periodontal parameters, and halitosis.

METHODS

60 healthy volunteers with severe periodontitis were randomized into two groups to receive periodontal therapy in a single session and lactobacillus or a placebo for 90 days. The test group received Lactobacillus reuteri, salivarius and acidophilus, and the control group received placebo with xylitol.

RESULTS

There was a reduction in the depth levels of the probing pocket and the level of relative attachment after 90 days (P< 0.01). Regarding bleeding after pocket probing, the full-mouth with lactobacillus groups also showed more reduction than the placebo group (P< 0.01). The same results were observed with the halitosis parameters (P< 0.01). Oral administration of lactobacillus reduced periodontal parameters and halitosis and could contribute to the beneficial effects on periodontal conditions and halitosis.

CLINICAL SIGNIFICANCE

Oral administration of lactobacillus reduced periodontal parameters and halitosis. At the dental office, dentists can consider using the beneficial effects of the probiotics on periodontal conditions and halitosis.

摘要

目的

评估乳酸杆菌与重度牙周炎辅助治疗疗效、牙周参数及口臭之间的临床关联。

方法

将60名患有重度牙周炎的健康志愿者随机分为两组,接受单次牙周治疗,并分别服用乳酸杆菌或安慰剂,为期90天。试验组服用罗伊氏乳杆菌、唾液乳杆菌和嗜酸乳杆菌,对照组服用含木糖醇的安慰剂。

结果

90天后,探诊深度水平和相对附着水平有所降低(P<0.01)。关于探诊后出血情况,服用乳酸杆菌的全口组也比安慰剂组有更明显的改善(P<0.01)。口臭参数方面也观察到了相同的结果(P<0.01)。口服乳酸杆菌可降低牙周参数和口臭程度,并有助于对牙周状况和口臭产生有益影响。

临床意义

口服乳酸杆菌可降低牙周参数和口臭程度。在牙科诊所,牙医可考虑利用益生菌对牙周状况和口臭的有益作用。

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