Yoon Youngwoo Bryan, Kim Minah, Lee Junhee, Cho Kang Ik K, Kwak Seoyeon, Lee Tae Young, Kwon Jun Soo
Department of Brain and Cognitive Sciences, Seoul National University, Seoul, Republic of Korea.
Institute of Human Behavioral Medicine, SNU-MRC, Seoul, Republic of Korea.
Psychiatry Investig. 2019 Mar;16(3):244-248. doi: 10.30773/pi.2018.11.18. Epub 2019 Mar 7.
We aim to investigate the effect of fronto-temporal transcranial direct current stimulation (tDCS) on the interactions among functional networks and its association with psychotic symptoms. In this pilot study, we will determine possible candidate functional networks and an adequate sample size for future research. Seven schizophrenia patients with treatment-refractory auditory hallucinations underwent tDCS twice daily for 5 days. Resting-state fMRI data and measures of the severity of psychotic symptoms were acquired at baseline and after completion of the tDCS sessions. At baseline, decreased functional network interaction was negatively correlated with increased hallucinatory behavior. After tDCS, the previously reduced functional network connectivity significantly increased. Our results showed that fronto-temporal tDCS could possibly remediate aberrant hallucination-related functional network interactions in patients with schizophrenia.
我们旨在研究额颞经颅直流电刺激（tDCS）对功能网络间相互作用的影响及其与精神症状的关联。在这项初步研究中，我们将确定未来研究可能的候选功能网络和合适的样本量。7名患有难治性幻听的精神分裂症患者每天接受两次tDCS，共5天。在基线期和tDCS疗程结束后采集静息态功能磁共振成像（fMRI）数据以及精神症状严重程度的测量指标。在基线期，功能网络相互作用的降低与幻觉行为的增加呈负相关。tDCS后，先前降低的功能网络连通性显著增加。我们的结果表明，额颞tDCS可能纠正精神分裂症患者中与幻觉相关的异常功能网络相互作用。
