Chumbley A B, Tuncay O C
Am J Orthod. 1986 Apr;89(4):312-4. doi: 10.1016/0002-9416(86)90053-9.
Prostaglandins (PGs) have been suggested as mediators of bone resorption. In addition, their presence in the periodontal tissues has also been demonstrated. To characterize the involvement of PGs in orthodontic tooth movement, indomethacin, an aspirin-like drug and a potent inhibitor of PG synthesis, was administered orally to six mongrel cats; another group of six animals served as controls. These animals were fitted with orthodontic appliances that consisted of coil springs stretching between the right side maxillary and mandibular canines and third premolars. The data for tooth-movement measurements were analyzed by repeated measures factorial analysis of variance. At the end of the 21-day experimental period, the rate of tooth movement in experimental animals was approximately one half of controls (P less than 0.01). Findings of this study imply a significant role for PGs in bone resorption during orthodontic therapy. It is recommended that aspirin-like drugs not be administered to patients undergoing orthodontic tooth movement as it may extend the treatment time.
前列腺素（PGs）被认为是骨吸收的介质。此外，它们在牙周组织中的存在也已得到证实。为了明确PGs在正畸牙齿移动中的作用，给6只杂种猫口服消炎痛，这是一种类似阿司匹林的药物，也是PG合成的强效抑制剂；另一组6只动物作为对照。这些动物安装了正畸矫治器，矫治器由拉伸在上颌右侧尖牙与下颌尖牙及第三前磨牙之间的螺旋弹簧组成。通过重复测量方差分析对牙齿移动测量数据进行分析。在21天的实验期结束时，实验动物的牙齿移动速率约为对照组的一半（P<0.01）。本研究结果表明PGs在正畸治疗期间的骨吸收中起重要作用。建议在正畸牙齿移动的患者中不要使用类似阿司匹林的药物，因为这可能会延长治疗时间。
