Giunta D, Keller J, Nielsen F F, Melsen B
Orthodontic Department, Dentistry School, University of Naples, Italy.
Am J Orthod Dentofacial Orthop. 1995 Oct;108(4):361-6. doi: 10.1016/s0889-5406(95)70033-1.
The purpose was to evaluate the influence of a prostaglandin inhibitor, indomethacin, on the tissue reaction related to orthodontic tooth movement. Sixteen miniature pigs were chosen for the study, eight of which received indomethacin perorally every day of the 39-day observation period. Sentalloy expansion springs (GAC, Central Islip, N.Y.) delivering 100 cN were inserted on a segmented arch between the central lower incisors. Intravital labeling with tetracycline was used for the evaluation of the rate of bone formation. After the pigs were killed, the bone turnover was evaluated on undecalcified methacrylate embedded sections and on microradiographs. The histomorphometric analysis of bone turnover revealed that the relative extent of resorption surfaces was decreased significantly in the indomethacin treated animals. Formation surfaces were also decreased although not significantly. The bone turnover, but not the mineralization rate, was influenced. The results corroborate the recommendation that prostaglandin inhibitors should be avoided during orthodontic treatments.
本研究旨在评估前列腺素抑制剂吲哚美辛对正畸牙齿移动相关组织反应的影响。选取16只小型猪进行研究，其中8只在为期39天的观察期内每天口服吲哚美辛。在双侧下颌中切牙之间的片段弓上插入施加100 cN力的Sentalloy扩弓弹簧（GAC，纽约州中央伊斯利普）。使用四环素进行活体标记以评估骨形成速率。处死猪后，在未脱钙的甲基丙烯酸酯包埋切片和显微放射照片上评估骨转换。骨转换的组织形态计量学分析显示，吲哚美辛处理组动物的吸收表面相对范围显著降低。形成表面也有所减少，尽管不显著。骨转换受到影响，但矿化速率未受影响。结果证实了正畸治疗期间应避免使用前列腺素抑制剂这一建议。
