Sir Henry Wellcome Post-Doctoral Fellow,Division of Psychiatry,University College London,UK.
Division of Psychiatry,University College London,UK.
Br J Psychiatry. 2019 Jul;215(1):428-433. doi: 10.1192/bjp.2019.39. Epub 2019 Mar 6.
Recent studies suggest psychotic and eating disorders can be comorbid and could have shared genetic liability. However, this comorbidity has been overlooked in the epidemiological literature.AimsTo test whether polygenic risk scores (PRS) for schizophrenia are associated with disordered eating behaviours and body mass index (BMI) in the general population.
Using data from the Avon Longitudinal Study of Parents and Children and random-effects logistic and linear regression models, we investigated the association between PRS for schizophrenia and self-reported disordered eating behaviours (binge eating, purging, fasting and excessive exercise) and BMI at 14, 16 and 18 years.
Of the 6920 children with available genetic data, 4473 (64.6%) and 5069 (73.3%) had at least one disordered eating and one BMI outcome measurement, respectively. An s.d. increase in PRS was associated with greater odds of having binge eating behaviours (odds ratio, 1.36; 95% CI 1.16-1.60) and lower BMI (coefficient, -0.03; 95% CI, -0.06 to -0.01).
Our findings suggest the presence of shared genetic risk between schizophrenia and binge eating behaviours. Intermediate phenotypes such as impaired social cognition and irritability, previously shown to be positively correlated in this sample with schizophrenia PRS, could represent risk factors for both phenotypes. Shared genetic liability between binge eating and schizophrenia could also explain higher rates of metabolic syndrome in individuals with schizophrenia, as binge eating could be a mediator of this association in drug-naïve individuals. The finding of an association between greater PRS and lower BMI, although consistent with existing epidemiological and genetic literature, requires further investigation.Declaration of interestNone.
最近的研究表明，精神病和饮食障碍可能并存，并可能具有共同的遗传易感性。然而，这种共病在流行病学文献中被忽视了。
测试精神分裂症的多基因风险评分 (PRS) 是否与一般人群的饮食障碍行为和体重指数 (BMI) 相关。
使用来自阿冯纵向研究父母和孩子的数据以及随机效应逻辑回归和线性回归模型，我们调查了精神分裂症 PRS 与自我报告的饮食障碍行为（暴食、催吐、禁食和过度运动）和 14、16 和 18 岁时的 BMI 之间的关联。
在具有可用遗传数据的 6920 名儿童中，分别有 4473 名（64.6%）和 5069 名（73.3%）至少有一次饮食障碍和一次 BMI 结果测量。PRS 的标准差增加与暴食行为的可能性更大相关（优势比，1.36；95%置信区间，1.16-1.60）和较低的 BMI（系数，-0.03；95%置信区间，-0.06 至-0.01）。
我们的研究结果表明精神分裂症和暴食行为之间存在共同的遗传风险。在这个样本中，以前显示与精神分裂症 PRS 呈正相关的中间表型，如受损的社会认知和易怒，可能代表两种表型的风险因素。暴食和精神分裂症之间的共同遗传易感性也可以解释精神分裂症患者中代谢综合征的发生率更高，因为暴食可能是这种关联在未用药个体中的中介因素。尽管与现有流行病学和遗传学文献一致，但发现较大的 PRS 与较低的 BMI 之间存在关联需要进一步研究。
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