Tirelli Medical Clinic, Pordenone, Italy.
Eur Rev Med Pharmacol Sci. 2019 Feb;23(4):1786-1788. doi: 10.26355/eurrev_201902_17141.
Fibromyalgia is a chronic disorder with a very complex symptomatology. Although generalized severe pain is considered to be the cardinal symptom of the disease, many other associated symptoms, especially non-restorative sleep, chronic fatigue, anxiety, and depressive symptoms also play a relevant role in the degree of disability characteristic of the disease. Ozone therapy, which is used to treat a wide range of diseases and seems to be particularly useful in the treatment of many chronic diseases, is thought to act by exerting a mild, transient, and controlled oxidative stress that promotes an up-regulation of the antioxidant system and a modulation of the immune system. According to these mechanisms of action, it was hypothesized that ozone therapy could be useful in fibromyalgia management, where the employed therapies are very often ineffective.
Sixty-five patients with fibromyalgia, according to the definition of the American College of Rheumatology (Arthritis Rheum 1990; 33: 160-172), were treated at the MEDE Clinic (Sacile, Pordenone, Italy) from February 2016 to October 2018. Females were 55 and males were 10; age ranged from 30 to 72 years, and the time from fibromyalgia diagnosis ranged from 0.5 to 33 years. Treatment was made by autohemotransfusion in 55 patients and by ozone rectal insufflations in 10 patients, according to SIOOT (Scientific Society of Oxygen Ozone Therapy) protocols, twice a week for one month and then twice a month as maintenance therapy.
We found a significative improvement (>50% of symptoms) in 45 patients (70%). No patient reported important side effects. In conclusion, at our knowledge, this is the largest study of patients with fibromyalgia treated with ozone therapy reported in the literature and it demonstrates that the ozone therapy is an effective treatment for fibromyalgia patients without significant side effects.
At the moment, ozone therapy seems a treatment that, also because without any side effect, is possible to be proposed to patients with fibromyalgia that are not obtaining adequate results from other available treatments and it can be considered as complementary/integrative medicine.
纤维肌痛是一种具有非常复杂症状的慢性疾病。虽然全身性严重疼痛被认为是该病的主要症状，但许多其他相关症状，尤其是非恢复性睡眠、慢性疲劳、焦虑和抑郁症状，也在该疾病的致残程度中起重要作用。臭氧治疗被用于治疗广泛的疾病，并且似乎对许多慢性疾病的治疗特别有效，其作用机制被认为是通过产生轻微、短暂和可控的氧化应激来发挥作用，这种应激促进抗氧化系统的上调和免疫系统的调节。根据这些作用机制，有人假设臭氧治疗可能对纤维肌痛的管理有用，因为所采用的治疗方法往往无效。
2016 年 2 月至 2018 年 10 月，意大利波代诺内省萨莱克的 MEDE 诊所（MEDE Clinic）对 65 名符合美国风湿病学会（Arthritis Rheum 1990；33：160-172）纤维肌痛定义的纤维肌痛患者进行了治疗。女性 55 例，男性 10 例；年龄 30-72 岁，从纤维肌痛诊断到治疗的时间为 0.5-33 年。根据 SIOOT（氧气臭氧治疗科学学会）方案，55 例患者接受自体血回输治疗，10 例患者接受臭氧直肠内灌输治疗，每周两次，持续一个月，然后每月两次作为维持治疗。
我们发现 45 例（70%）患者的症状有显著改善（>50%）。没有患者报告有重要的副作用。总之，就我们所知，这是文献中报道的最大规模的纤维肌痛患者接受臭氧治疗的研究，它表明臭氧治疗是一种有效的纤维肌痛治疗方法，没有明显的副作用。
目前，臭氧治疗似乎是一种治疗方法，因为没有任何副作用，可以向那些从其他可用治疗方法中没有获得满意效果的纤维肌痛患者提出，并且可以被视为补充/整合医学。
