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绿原酸可减轻高脂喂养小鼠的肥胖并调节其肠道微生物群。

Chlorogenic acid alleviates obesity and modulates gut microbiota in high-fat-fed mice.

作者信息

Wang Zhengyu, Lam Ka-Lung, Hu Jiamiao, Ge Shenghan, Zhou Arong, Zheng Baodong, Zeng Shaoxiao, Lin Shaoling

机构信息

College of Food Science Fujian Agriculture and Forestry University Fuzhou China.

Fujian Provincial Key Laboratory of Quality Science and Processing Technology in Special Starch Fujian Agriculture and Forestry University Fuzhou China.

出版信息

Food Sci Nutr. 2019 Jan 28;7(2):579-588. doi: 10.1002/fsn3.868. eCollection 2019 Feb.

DOI:10.1002/fsn3.868
PMID:30847137
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6392816/
Abstract

To evaluate the anti-obesity effects of chlorogenic acid (CGA), the mice were fed a high-fat diet (HFD) upon chlorogenic acid treatment for 6 weeks. The results showed administration of chlorogenic acid (150 mg per kg per day) remarkably promoted body loss, reduced lipid levels in plasma and altered mRNA expression of lipogenesis and lipolysis related genes in adipose tissue. Moreover, chlorogenic acid also reversed the HFD-induced gut microbiota dysbiosis, including significantly inhibiting the growth of and raising the growth of . Overall, the amelioration of HFD-induced gut microbiota dysbiosis by chlorogenic acid may contribute, at least partially, to its beneficial effects on ameliorating HFD-induced obesity.

摘要

为评估绿原酸（CGA）的抗肥胖作用，在给予绿原酸治疗6周期间，给小鼠喂食高脂饮食（HFD）。结果显示，给予绿原酸（每天每千克150毫克）显著促进体重减轻，降低血浆脂质水平，并改变脂肪组织中脂肪生成和脂肪分解相关基因的mRNA表达。此外，绿原酸还逆转了高脂饮食诱导的肠道微生物群失调，包括显著抑制 的生长并促进 的生长。总体而言，绿原酸对高脂饮食诱导的肠道微生物群失调的改善作用可能至少部分地促成了其对改善高脂饮食诱导的肥胖的有益作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86bf/6392816/faf72ff19abd/FSN3-7-579-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86bf/6392816/7905be12fdbf/FSN3-7-579-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86bf/6392816/e77476203f75/FSN3-7-579-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86bf/6392816/60eacee9fe0a/FSN3-7-579-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86bf/6392816/84dddaa57176/FSN3-7-579-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86bf/6392816/faf72ff19abd/FSN3-7-579-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86bf/6392816/7905be12fdbf/FSN3-7-579-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86bf/6392816/e77476203f75/FSN3-7-579-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86bf/6392816/60eacee9fe0a/FSN3-7-579-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86bf/6392816/84dddaa57176/FSN3-7-579-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86bf/6392816/faf72ff19abd/FSN3-7-579-g005.jpg

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