Department of Translational Research on New Technologies in Medicine and Surgery University of Pisa Pisa Italy.
Laboratoire des systèmes perceptifs Département d'études cognitives École normale supérieure PSL University CNRS 75005 Paris France.
Ann Clin Transl Neurol. 2018 Dec 28;6(2):274-284. doi: 10.1002/acn3.698. eCollection 2019 Feb.
The aim of this study was to investigate whether short-term inverse occlusion, combined with moderate physical exercise, could promote the recovery of visual acuity and stereopsis in a group of adult anisometropic amblyopes.
Ten adult anisometropic patients underwent six brief (2 h) training sessions over a period of 4 weeks. Each training session consisted in the occlusion of the amblyopic eye combined with physical exercise (intermittent cycling on a stationary bike). Visual acuity (measured with ETDRS charts), stereoacuity (measured with the TNO test), and sensory eye dominance (measured with binocular rivalry) were tested before and after each training session, as well as in follow-up visits performed 1 month, 3 months, and 1 year after the end of the training.
After six brief (2 h) training sessions, visual acuity improved in all 10 patients (0.15 ± 0.02 LogMar), and six of them also recovered stereopsis. The improvement was preserved for up to 1 year after training. A pilot experiment suggested that physical activity might play an important role for the recovery of visual acuity and stereopsis.
Our results suggest a noninvasive training strategy for adult human amblyopia based on an inverse-occlusion procedure combined with physical exercise.
本研究旨在探讨短期反向遮盖联合适度体育锻炼是否能促进一组成人屈光参差性弱视患者视力和立体视的恢复。
10 名成人屈光参差性弱视患者接受了为期 4 周的 6 次短暂（2 小时）训练。每次训练都包括遮盖弱视眼和体育锻炼（在固定自行车上间歇性骑行）。在每次训练前后以及训练结束后 1 个月、3 个月和 1 年进行随访时，测量了视力（用 ETDRS 图表测量）、立体视（用 TNO 测试测量）和感觉眼优势（用双眼竞争测量）。
在 6 次短暂（2 小时）的训练后，所有 10 名患者的视力均有改善（0.15±0.02 LogMar），其中 6 名患者还恢复了立体视。这种改善在训练结束后 1 年内保持不变。一项初步实验表明，体育活动可能对视敏度和立体视的恢复起着重要作用。
我们的结果表明，基于反向遮盖程序联合体育锻炼的非侵入性训练策略可能是一种治疗成人弱视的方法。
