疱疹性口炎患者的染色体断裂和姐妹染色单体交换（SCE）

Chromosomal breaks and sister chromatid exchanges (SCE) in patients with herpetic stomatitis.

作者信息

Zervou-Valvi F, Bazopoulou-Kyrkanidou E, Angelopoulos A P

出版信息

J Oral Pathol. 1986 Mar;15(3):151-4. doi: 10.1111/j.1600-0714.1986.tb00597.x.

DOI:10.1111/j.1600-0714.1986.tb00597.x

Abstract

Chromosomal breakage and sister-chromatid exchanges (SCE) were studied in peripheral lymphocytes of 9 patients with primary herpetic stomatitis (PHS), 12 patients with secondary herpetic stomatitis (SHS) and 12 controls. The incidence of chromosomal breakage was significantly higher in PHS patients (mean 23%, P. = 0.0002) and in SHS patients (mean 20.25%, P. = 0.0003) compared to the controls (mean 4.2%). The incidence of SCE per 46 chromosomes was significantly higher in SHS patients (mean 16.564) compared with (P. less than 0.001) the controls (mean 11.367) and compared with (P. = 0.006) the PHS patients (mean 12.131). It is concluded that both PHS and SHS patients exhibit structural chromosomal damage; SHS patients in addition exhibit more repaired chromosomal lesions.

摘要

对9例原发性疱疹性口炎（PHS）患者、12例继发性疱疹性口炎（SHS）患者和12名对照者的外周血淋巴细胞进行了染色体断裂和姐妹染色单体交换（SCE）研究。与对照组（平均4.2%）相比，PHS患者（平均23%，P = 0.0002）和SHS患者（平均20.25%，P = 0.0003）的染色体断裂发生率显著更高。与对照组（平均11.367）相比（P < 0.001），每46条染色体的SCE发生率在SHS患者中（平均16.564）显著更高，与PHS患者（平均12.131）相比（P = 0.006）也显著更高。得出的结论是，PHS和SHS患者均表现出染色体结构损伤；此外，SHS患者表现出更多修复后的染色体损伤。