评价 11 种离子浸出修复材料的 F、Ca 和 P 释放以及显微硬度，以及使用新型含 Ca/P 氟化物涂料的再矿化效果。

Evaluation of F, Ca, and P release and microhardness of eleven ion-leaching restorative materials and the recharge efficacy using a new Ca/P containing fluoride varnish.

机构信息

Melbourne Dental School, The University of Melbourne, Melbourne, VIC, Australia.

Faculty of Dentistry, Prince Philip Dental Hospital, University of Hong Kong, Hong Kong SAR, China.

出版信息

J Dent. 2020 Nov;102:103474. doi: 10.1016/j.jdent.2020.103474. Epub 2020 Sep 14.

DOI:10.1016/j.jdent.2020.103474

PMID:32941973

Abstract

OBJECTIVES

The objectives of this study were to evaluate fluoride (F), calcium (Ca), and phosphate (P) release of ion-leaching restorative materials (ILMs), their recharge efficacy with a Ca/P-containing F varnish, and relative microhardness.

METHODS

Thirteen groups of materials were investigated. Cylindrical-shaped specimens were fabricated. Deionised water or lactic-acid solution were used as the storage media. Solutions were changed after 1d, 4d, 7d, and 14d of ion release and at the same periods after recharge with MI Varnish (7 -h storage). F, Ca, and P measurements were accomplished using a fluoride-ion selective electrode, atomic absorption spectrometry, and colourimetric method by spectrophotometer, respectively. Relative Vickers hardness was proceeded with similar specimens used in the F assay (4 periods). SEM/EDS was additionally performed. Statistical analyses were calculated in each parameter (p < 0.05).

RESULT

Hardness of several ILMs immediately increased after recharge. After 28d, Ketac Universal [a high-viscosity glass-ionomer cement (HVGIC)] showed the highest hardness similar to the resin composite control. Although 2 HVGICs (Zirconomer and Equia Forte Fil) ranked as first and second for F release/re-release, some HVGICs had inferior or comparable F capacity to RMGICs (Fuji VIII and Fuji II LC) and a resin-based (RB) ILM (Cention N). Cention N, Activa-Restorative (RB-ILM), and Zirconomer were the top-3 ranking for Ca release/re-release. Activa-Restorative showed the highest P release, whereas Cention N displayed the greatest recharge ability for P.

CONCLUSIONS

Zirconomer showed a versatile performance for ion-release/re-release, especially for F. Cention N had excellent capacity in relation to Ca release and recharge ability of Ca/P.

CLINICAL SIGNIFICANCE

With the F varnish recharge protocol, Zirconomer, Equia Forte, and Fuji VIII seems to have an ability to inhibit initial caries initiation. Cention N is a promising resin-based material that could be an alternative for high caries risk patients due to the high Ca release/recharge with acceptable F release.

摘要

目的

本研究的目的是评估离子浸出修复材料（ILM）的氟（F）、钙（Ca）和磷（P）释放情况，用含 Ca/P 的 F 清漆对其进行再充电的效果，以及相对显微硬度。

方法

研究了 13 组材料。制作圆柱形试件。使用去离子水或乳酸溶液作为储存介质。在离子释放后第 1、4、7 和 14 天以及用 MI 清漆（7 h 储存）再充电后相同时间更换溶液。使用氟离子选择性电极、原子吸收光谱法和分光光度计比色法分别完成 F、Ca 和 P 的测量。相对维氏硬度用用于 F 测定的类似试件进行（4 个周期）。此外还进行了 SEM/EDS。在每个参数（p<0.05）中计算了统计分析。

结果

几种 ILM 的硬度在再充电后立即增加。28d 后，Ketac Universal（一种高粘度玻璃离子水泥（HVGIC））显示出与树脂复合材料对照物相似的最高硬度。尽管 2 种 HVGIC（Zirconomer 和 Equia Forte Fil）在 F 释放/再释放方面排名第一和第二，但一些 HVGIC 的 F 容量与 RMGIC（Fuji VIII 和 Fuji II LC）和基于树脂的（RB）ILM（Cention N）相当或更低。Cention N、Activa-Restorative（RB-ILM）和 Zirconomer 是 Ca 释放/再释放的前 3 名。Activa-Restorative 显示出最高的 P 释放量，而 Cention N 显示出最大的 P 再充电能力。