Coppen A, Swade C, Wood K
Clin Chim Acta. 1978 Jul 1;87(1):165-8. doi: 10.1016/0009-8981(78)90071-2.
The uptake of 5-hydroxytryptamine (5-HT) by blood platelets from controls, depressed patients and recovered depressed patients has been determined using short incubation times and low substrate concentrations. The affinity of serotonin for the platelet membrane appears to be normal in acutely depressed and recovered depressed patients. The capacity of transport of 5-HT through the platelet membrane is impaired in these depressive patients and this impairment is independent of the psychiatric status of the patients and is discussed in the light of the electrolyte and enzyme disturbances that are associated with depressive illness.
利用短孵育时间和低底物浓度，测定了对照组、抑郁症患者和康复的抑郁症患者血小板对5-羟色胺（5-HT）的摄取。在急性抑郁症患者和康复的抑郁症患者中，血清素对血小板膜的亲和力似乎正常。这些抑郁症患者中5-HT通过血小板膜的转运能力受损，且这种损害与患者的精神状态无关，并根据与抑郁症相关的电解质和酶紊乱进行了讨论。
