塑造细胞迁移景观的非规范过程。
Non-canonical processes that shape the cell migration landscape.
机构信息
Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109, USA.
Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
出版信息
Curr Opin Cell Biol. 2019 Apr;57:123-134. doi: 10.1016/j.ceb.2018.12.013. Epub 2019 Mar 7.
Abstract
Migration is a vital, intricate, and multi-faceted process that involves the entire cell, entails the integration of multiple external cues and, at times, necessitates high-level coordination among fields of cells that can be physically attached or not, depending on the physiological setting. Recent advances have highlighted the essential role of cellular components that have not been traditionally considered when studying cell migration. This review details how much we recently learned by studying the role of intermediate filaments, the nucleus, extracellular vesicles, and mitochondria during cell migration.
摘要
迁移是一个重要的、复杂的、多方面的过程，涉及整个细胞，需要整合多个外部线索，有时需要在可以物理连接或不连接的细胞区域之间进行高级协调，这取决于生理环境。最近的进展强调了在研究细胞迁移时传统上不被考虑的细胞成分的重要作用。这篇综述详细介绍了我们最近通过研究细胞迁移过程中中间丝、核、细胞外囊泡和线粒体的作用所学到的知识。
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