Morgan A D, Connaughton J J, Catterall J R, Shapiro C M, Douglas N J, Flenley D C
Thorax. 1986 Jan;41(1):39-41. doi: 10.1136/thx.41.1.39.
To investigate whether mast cell degranulation was important in producing nocturnal asthma, the effect of a single high dose of nebulised sodium cromoglycate on overnight bronchoconstriction, oxygen saturation, and breathing patterns in eight patients with nocturnal wheeze was examined. The study took the form of a double blind placebo controlled crossover comparison. Treatment with cromoglycate did not reduce the overnight fall in FEV1 or FVC, although it was associated with improved nocturnal oxygenation. This study suggests that mast cell degranulation may not be important in the pathogenesis of nocturnal asthma.
为研究肥大细胞脱颗粒在夜间哮喘发作中是否起重要作用，对8例夜间喘息患者给予单次高剂量雾化吸入色甘酸钠，观察其对夜间支气管收缩、血氧饱和度及呼吸模式的影响。本研究采用双盲安慰剂对照交叉比较的形式。色甘酸钠治疗虽可改善夜间氧合，但并未减少FEV1或FVC的夜间下降。本研究提示，肥大细胞脱颗粒在夜间哮喘的发病机制中可能并不重要。
