Department of Psychiatry and Medical Psychology, The First Affiliated Hospital, College of Clinical Medicine, Guangdong Pharmaceutical University, Guangzhou, P.R.C.
Zhongshan People's Hospital, Zhongshan City, Dongguan, P.R.C.
Curr Oncol. 2019 Feb;26(1):e48-e56. doi: 10.3747/co.26.4126. Epub 2019 Feb 1.
We examined the effects of magnanimous therapy on psychological coping, adjustment, living function, and survival rate in patients with advanced lung cancer.
Patients with advanced lung cancer ( = 145) matched by demographics and medical variables were randomly assigned to an individual computer magnanimous therapy group (ic-mt), a group computer magnanimous therapy group (gc-mt), or a control group (ctrl). Over 2 weeks, the ic-mt and gc-mt groups received eight 40-minute sessions of ic-mt or gc-mt respectively, plus usual care; the ctrl group received only usual care. The Cancer Coping Modes Questionnaire (ccmq), the Psychological Adjustment Scale for Cancer Patients (pascp), and the Functional Living Index-Cancer (flic) were assessed at baseline and 2 weeks later. The relationships of changes in those indicators were analyzed, and survival rates were compared.
The psychological coping style, adjustment, and living function of the ic-mt and gc-mt groups improved significantly after the intervention ( < 0.01). After 2 weeks, significant ( < 0.01) differences between the treatment groups and the ctrl group in coping style, adjustment, and living function suggested successful therapy. The changes in living function were correlated with changes in psychological coping and adjustment. No difference in efficacy between ic-mt and gc-mt was observed. The survival rate was 31.84% in the ic-mt group and 9.375% in the ctrl group at 2 years after the intervention.
In patients with advanced lung cancer, ic-mt and gc-mt were associated with positive short-term effects on psychological coping style, adjustment, and living function, although the magnitude of the effect did not differ significantly between the intervention approaches. The effects on living function are partly mediated by improvements in psychological coping and adjustment.
我们考察了宽宏疗法对晚期肺癌患者心理应对、调整、生活功能和生存率的影响。
按人口统计学和医学变量匹配的晚期肺癌患者（n=145）被随机分配到个体计算机宽宏疗法组（ic-mt）、团体计算机宽宏疗法组（gc-mt）或对照组（ctrl）。在 2 周内，ic-mt 和 gc-mt 组分别接受 8 次 40 分钟的 ic-mt 或 gc-mt 治疗，外加常规护理；ctrl 组仅接受常规护理。在基线和 2 周后评估癌症应对模式问卷（ccmq）、癌症患者心理调整量表（pascp）和癌症患者功能生活指数（flic）。分析这些指标变化的关系，并比较生存率。
干预后 ic-mt 和 gc-mt 组的心理应对方式、调整和生活功能明显改善（<0.01）。干预 2 周后，治疗组与 ctrl 组在应对方式、调整和生活功能方面的差异具有统计学意义（<0.01），提示治疗成功。生活功能的变化与心理应对和调整的变化相关。ic-mt 和 gc-mt 之间的疗效无差异。干预 2 年后，ic-mt 组的生存率为 31.84%，ctrl 组为 9.375%。
在晚期肺癌患者中，ic-mt 和 gc-mt 与心理应对方式、调整和生活功能的短期积极效果相关，尽管干预方法之间的效果差异无统计学意义。对生活功能的影响部分通过心理应对和调整的改善来介导。
