Pogoda Janice M, Patricio Galilea, McEligot Archana J
Cipher Biostatistics & Reporting, Reno, Nevada.
California State University, Fullerton, Health Science Department.
Calif J Health Promot. 2018;16(1):16-23.
Caffeine is ubiquitous in foods, supplements, and medications and has been hypothesized to be associated with several health-related outcomes, including mental health disorders such as anxiety. We explored a possible relationship between caffeine consumption and depression using data from the National Health and Nutrition Examination Survey (NHANES).
Data from 1,342 adult NHANES participants were included. Statistical software for complex survey sample designs was used to perform two multivariable logistic regressions with a binary indicator of depression as the dependent variable: one using dietary caffeine consumption and one using the caffeine metabolite AAMU as the independent variable. Both analyses were adjusted for gender, race/ethnicity, smoking status, and use of anti-depressants.
We observed a descriptive, albeit non-significant ( = 0.12), pattern of increasing odds of depression with increasing levels of the AAMU caffeine metabolite.
Our finding of a possible association between caffeine metabolite level and depression is compelling because it is independent of self-reported caffeine consumption. Prospective studies are warranted to further explore the temporal relationship.
咖啡因在食品、补充剂和药物中普遍存在，据推测它与多种健康相关结果有关，包括焦虑等精神健康障碍。我们利用美国国家健康与营养检查调查（NHANES）的数据，探讨了咖啡因摄入量与抑郁症之间的可能关系。
纳入了1342名NHANES成年参与者的数据。使用复杂调查样本设计的统计软件进行了两个多变量逻辑回归分析，以抑郁症的二元指标作为因变量：一个使用膳食咖啡因摄入量作为自变量，另一个使用咖啡因代谢物AAMU作为自变量。两项分析均对性别、种族/族裔、吸烟状况和抗抑郁药的使用情况进行了调整。
我们观察到，随着AAMU咖啡因代谢物水平的升高，抑郁症的患病几率呈现出一种描述性的、尽管不显著（P = 0.12）的上升趋势。
我们发现咖啡因代谢物水平与抑郁症之间可能存在关联，这一发现很有说服力，因为它独立于自我报告的咖啡因摄入量。有必要进行前瞻性研究以进一步探讨这种时间关系。
