Parmeciano Di Noto Gisela, Molina María Carolina, Quiroga Cecilia
Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Tecnológicas, Instituto de Investigaciones en Microbiología y Parasitología Médica (IMPAM), Facultad de Medicina, Buenos Aires, Argentina.
Front Genet. 2019 Feb 22;10:57. doi: 10.3389/fgene.2019.00057. eCollection 2019.
Multidrug resistant bacteria are a serious worldwide problem, especially carbapenem-resistant (such as and ), and . Since the emergence of extensive and pan-drug resistant bacteria there are few antibiotics left to treat patients, thus novel RNA-based strategies are being considered. Here, we examine the current situation of different non-coding RNAs found in bacteria as well as their function and potential application as antimicrobial agents. Furthermore, we discuss the factors that may contribute in the efficient development of RNA-based drugs, the limitations for their implementation and the use of nanocarriers for delivery.
多重耐药菌是一个严重的全球性问题，尤其是对碳青霉烯类耐药的细菌（如 和 以及 ）。自从广泛耐药菌和泛耐药菌出现以来，可用于治疗患者的抗生素所剩无几，因此正在考虑基于RNA的新策略。在这里，我们研究了细菌中发现的不同非编码RNA的现状，以及它们作为抗菌剂的功能和潜在应用。此外，我们还讨论了可能有助于基于RNA的药物高效开发的因素、其实施的局限性以及用于递送的纳米载体的使用。
