Wang Congan, Zhang Xinghe, Wang Dandan, Shi Bin, Sun Guodong, Zhang Bo, Zou Liang
School of Acupuncture-Tuina, Shandong University of Traditional Chinese Medicine.
Affiliated Hospital of Shandong Academy of Medical Sciences.
Medicine (Baltimore). 2019 Mar;98(10):e14775. doi: 10.1097/MD.0000000000014775.
Functional constipation (FC) is one of the most common functional gastrointestinal disorders, which brings many negative impacts to the patient's daily life. In the treatment of FC, Tuina (Chinese massage) is often performed as complementary and alternative medicine and shows a good effect in many clinical trials. However, no high-quality systematic review was taken to show the efficacy and safety of Tuina for FC.
The electronic databases of Cochrane Library, Web of Science (WOS), MEDLINE, Wiley, Springer, EMBASE, Chinese Science Citation Database, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, Chinese Scientific Journal Database, Wan-fang database, and other databases will be searched from the establishment to February 1, 2019. Randomized controlled trials about this theme will be retrieved. Independent reviewers will operate literature retrieval, duplication removing, screening, quality evaluation, data analyses by EndNote (X9) and Review Manager (5.3.5). Meta-analysis, subgroup analysis and/or descriptive analysis will be performed based on the included data form.
Evidenced outcome will be provided from defecation frequency, stool consistency (Bistol stool scale), success rates, quality of life, proportion of patients using laxatives, and adverse effects.
This review will provide evidence of whether Tuina is an effective and safe intervention for FC.
This protocol of systematic review has been registered on PROSPERO website (No. CRD42019119722).
功能性便秘（FC）是最常见的功能性胃肠疾病之一，给患者的日常生活带来诸多负面影响。在FC的治疗中，推拿（中医按摩）常作为补充和替代医学手段，且在许多临床试验中显示出良好效果。然而，尚无高质量的系统评价来表明推拿治疗FC的疗效和安全性。
将检索Cochrane图书馆、科学网（WOS）、MEDLINE、Wiley、Springer、EMBASE、中国科学引文数据库、中国知网、中国生物医学文献数据库、中国科学期刊数据库、万方数据库等电子数据库，检索时间从建库至2019年2月1日。检索关于该主题的随机对照试验。独立 reviewers 将通过EndNote（X9）和Review Manager（5.3.5）进行文献检索、去重、筛选、质量评估和数据分析。将根据纳入的数据形式进行Meta分析、亚组分析和/或描述性分析。
将从排便频率、大便性状（布里斯托大便分类法）、成功率、生活质量、使用泻药的患者比例和不良反应等方面提供证据性结果。
本综述将提供证据证明推拿对FC是否为一种有效且安全的干预措施。
本系统评价方案已在PROSPERO网站注册（注册号：CRD42019119722）。
