Fernández-Vigo José Ignacio, Kudsieh Bachar, Macarro-Merino Ana, Arriola-Villalobos Pedro, Martínez-de-la-Casa José María, García-Feijóo Julián, Fernández-Vigo José Ángel
Department of Ophthalmology, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria (IdISSC), Madrid, Spain.
Centro Internacional de Oftalmología Avanzada, Madrid, Spain.
Eur J Ophthalmol. 2020 Jul;30(4):756-763. doi: 10.1177/1120672119834472. Epub 2019 Mar 12.
To assess the reproducibility of swept-source optical coherence tomography angiography (SS-OCTA) for macular and optic nerve head (ONH) vessel density (VD).
Cross-sectional study using the Triton OCTA (Topcon, Tokyo, Japan), for VD (%) measurements in 40 eyes of 40 healthy subjects on two 6 × 6 mm scans of the macula and ONH across five subfields (central, superior, inferior, temporal, and nasal) at different segmentation levels: superficial capillary plexus (SCP), deep capillary plexus (DCP), outer retina, and choriocapillaris. Reproducibility values were summarized as intraclass correlation coefficients (ICCs) and coefficients of variations (CV).
ICCs for the macular VD measurements in the central zone were 0.874, 0.770, 0.575, 0.718 at the levels SCP, DCP, outer retina, and choriocapillaris, respectively, while worse ICCs were obtained for the parafoveal subfields (ICC ⩽ 0.589); CVs were 2.8%-6.7%. The reproducibility of the ONH superficial VD was ICC = 0.941 for the papillary region and was ICC = 0.499-0.853 for the peripapillary zone; CVs ranged from 4.8% to 17%. Peripapillary VD showed an ICC = 0.533-0.770 in the DCP layer, and 0.572-0.828 in the choriocapillaris. Lowest VD were obtained for the macular SCP and DCP (23% and 22%, respectively), in the foveal zone, while greatest VD were recorded in the nasal and temporal peripapillary subfields at the level of the choriocapillaris (both 68%).
The new SS-OCTA software served to quantify macular and ONH VD with a reproducibility that was good in the central zones (foveal and papillary, respectively) and moderate in the peripheral zones (parafoveal and peripapillary).
评估扫频源光学相干断层扫描血管造影（SS-OCTA）测量黄斑和视神经乳头（ONH）血管密度（VD）的可重复性。
采用横断面研究，使用Triton OCTA（日本东京拓普康公司），对40名健康受试者的40只眼睛进行VD（%）测量，在黄斑和ONH的两次6×6mm扫描中，跨越五个子区域（中央、上方、下方、颞侧和鼻侧），在不同的分割水平：浅表毛细血管丛（SCP）、深层毛细血管丛（DCP）、外层视网膜和脉络膜毛细血管层。可重复性值总结为组内相关系数（ICC）和变异系数（CV）。
黄斑VD测量在中央区域SCP、DCP、外层视网膜和脉络膜毛细血管层水平的ICC分别为0.874、0.770、0.575、0.718，而黄斑旁子区域的ICC较差（ICC≤0.589）；CV为2.8%-6.7%。ONH浅表VD的可重复性在乳头区域ICC=0.941，在乳头周围区域ICC=0.499-0.853；CV范围为4.8%至17%。乳头周围VD在DCP层ICC=0.533-0.770，在脉络膜毛细血管层ICC=0.572-0.828。黄斑SCP和DCP在中央凹区域的VD最低（分别为23%和22%），而脉络膜毛细血管层水平在鼻侧和颞侧乳头周围子区域的VD最高（均为68%）。
新型SS-OCTA软件用于量化黄斑和ONH的VD，其可重复性在中央区域（分别为中央凹和乳头）良好，在周边区域（黄斑旁和乳头周围）中等。
