Blicharz Leszek, Rudnicka Lidia, Samochocki Zbigniew
Department of Dermatology, Medical University of Warsaw, Warsaw, Poland.
Postepy Dermatol Alergol. 2019 Feb;36(1):11-17. doi: 10.5114/ada.2019.82821. Epub 2019 Feb 22.
Atopic dermatitis is a common, recurrent pruritic dermatosis with a complex pathogenesis. It has been associated with disordered patterns of immunological response and impaired epithelial barrier integrity. These features predispose the patients to robust colonization of skin lesions by . Virulence factors of (e.g. superantigens, α- and δ-toxin, protein A) have been shown to exacerbate and perpetuate the course of atopic dermatitis. Novel therapeutic options with potential for restoring natural microbiome composition are being elaborated and may enter clinical practice in the future.
特应性皮炎是一种常见的、复发性瘙痒性皮肤病，其发病机制复杂。它与免疫反应模式紊乱和上皮屏障完整性受损有关。这些特征使患者易发生皮肤病变的强力定植。（例如超抗原、α-和δ-毒素、蛋白A）的毒力因子已被证明会加剧并使特应性皮炎的病程持续。正在研发具有恢复天然微生物群组成潜力的新型治疗选择，未来可能会进入临床实践。
