了解生物膜和超抗原在慢性鼻-鼻窦炎中的作用。
Understanding the Role of Biofilms and Superantigens in Chronic Rhinosinusitis.
作者信息
Maina Ivy W, Patel Neil N, Cohen Noam A
机构信息
Department of Otorhinolaryngology-Head and Neck Surgery, Division of Rhinology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA.
Philadelphia Veterans Affairs Medical Center, Philadelphia, PA.
出版信息
Curr Otorhinolaryngol Rep. 2018 Sep;6(3):253-262. doi: 10.1007/s40136-018-0212-6. Epub 2018 Jul 26.
Abstract
PURPOSE OF REVIEW
This review explores recent discoveries in our understanding of how biofilms and superantigens contribute to the pathogenesis of chronic rhinosinusitis (CRS). It also examines clinical implications and novel treatment approaches for biofilm associated CRS.
RECENT FINDINGS
While the role of biofilms in CRS has been studied for 14 years, research interest has now turned toward elucidating new methods of biofilm detection, microbial diversity, and novel treatment approaches. Recent studies on biofilm superantigens aim to clarify the immunological mechanisms of upper airway inflammation, particularly the type-2 response seen in nasal polyposis.
SUMMARY
Biofilms are a topic of research interest for their role in the pathogenesis of chronic rhinosinusitis, particularly when they elute superantigens. New studies on this topic focus on the molecular and cellular mechanisms at play.
摘要
综述目的
本综述探讨了近期在理解生物膜和超抗原如何促成慢性鼻-鼻窦炎（CRS）发病机制方面的新发现。还研究了生物膜相关CRS的临床意义和新的治疗方法。
最新发现
虽然生物膜在CRS中的作用已被研究了14年，但现在研究兴趣已转向阐明生物膜检测的新方法、微生物多样性和新的治疗方法。近期关于生物膜超抗原的研究旨在阐明上呼吸道炎症的免疫机制，尤其是鼻息肉中所见的2型反应。
总结
生物膜因其在慢性鼻-鼻窦炎发病机制中的作用而成为研究热点，尤其是当它们释放超抗原时。关于这一主题的新研究聚焦于其中的分子和细胞机制。
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